Demyelination versus remyelination in progressive multiple sclerosis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Demyelination versus remyelination in progressive multiple sclerosis. / Bramow, Stephan; Frischer, Josa M; Lassmann, Hans; Koch-Henriksen, Nils; Lucchinetti, Claudia F; Sørensen, Per S; Laursen, Henning.

I: Brain, Bind 133, Nr. 10, 01.10.2010, s. 2983-98.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bramow, S, Frischer, JM, Lassmann, H, Koch-Henriksen, N, Lucchinetti, CF, Sørensen, PS & Laursen, H 2010, 'Demyelination versus remyelination in progressive multiple sclerosis', Brain, bind 133, nr. 10, s. 2983-98. https://doi.org/10.1093/brain/awq250

APA

Bramow, S., Frischer, J. M., Lassmann, H., Koch-Henriksen, N., Lucchinetti, C. F., Sørensen, P. S., & Laursen, H. (2010). Demyelination versus remyelination in progressive multiple sclerosis. Brain, 133(10), 2983-98. https://doi.org/10.1093/brain/awq250

Vancouver

Bramow S, Frischer JM, Lassmann H, Koch-Henriksen N, Lucchinetti CF, Sørensen PS o.a. Demyelination versus remyelination in progressive multiple sclerosis. Brain. 2010 okt. 1;133(10):2983-98. https://doi.org/10.1093/brain/awq250

Author

Bramow, Stephan ; Frischer, Josa M ; Lassmann, Hans ; Koch-Henriksen, Nils ; Lucchinetti, Claudia F ; Sørensen, Per S ; Laursen, Henning. / Demyelination versus remyelination in progressive multiple sclerosis. I: Brain. 2010 ; Bind 133, Nr. 10. s. 2983-98.

Bibtex

@article{41ab40b7edd446bbbbf4a62fb60ac6dc,
title = "Demyelination versus remyelination in progressive multiple sclerosis",
abstract = "The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments for other plaque types and plaque number (P",
author = "Stephan Bramow and Frischer, {Josa M} and Hans Lassmann and Nils Koch-Henriksen and Lucchinetti, {Claudia F} and S{\o}rensen, {Per S} and Henning Laursen",
year = "2010",
month = oct,
day = "1",
doi = "http://dx.doi.org/10.1093/brain/awq250",
language = "English",
volume = "133",
pages = "2983--98",
journal = "Brain",
issn = "0006-8950",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Demyelination versus remyelination in progressive multiple sclerosis

AU - Bramow, Stephan

AU - Frischer, Josa M

AU - Lassmann, Hans

AU - Koch-Henriksen, Nils

AU - Lucchinetti, Claudia F

AU - Sørensen, Per S

AU - Laursen, Henning

PY - 2010/10/1

Y1 - 2010/10/1

N2 - The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments for other plaque types and plaque number (P

AB - The causes of incomplete remyelination in progressive multiple sclerosis are unknown, as are the pathological correlates of the different clinical characteristics of patients with primary and secondary progressive disease. We analysed brains and spinal cords from 51 patients with progressive multiple sclerosis by planimetry. Thirteen patients with primary progressive disease were compared with 34 with secondary progressive disease. In patients with secondary progressive multiple sclerosis, we found larger brain plaques, more demyelination in total and higher brain loads of active demyelination compared with patients with primary progressive disease. In addition, the brain density of plaques with high-grade inflammation and active demyelination was highest in secondary progressive multiple sclerosis and remained ~18% higher than in primary progressive multiple sclerosis after adjustments for other plaque types and plaque number (P

U2 - http://dx.doi.org/10.1093/brain/awq250

DO - http://dx.doi.org/10.1093/brain/awq250

M3 - Journal article

VL - 133

SP - 2983

EP - 2998

JO - Brain

JF - Brain

SN - 0006-8950

IS - 10

ER -

ID: 34093181