Educational attainment does not influence brain aging

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Dokumenter

  • Fulltext

    Forlagets udgivne version, 720 KB, PDF-dokument

  • Lars Nyberg
  • Fredrik Magnussen
  • Anders Lundquist
  • William Baaré
  • David Bartrés-Faz
  • Lars Bertram
  • Andreas M. Brandmaier
  • Christian A. Drevon
  • Klaus Ebmeier
  • Paolo Ghisletta
  • Richard N. Henson
  • Carme Junqué
  • Rogier Kievit
  • Maike Kleemeyer
  • Ethan Knights
  • Simone Kühn
  • Ulman Lindenberger
  • Brenda W.J.H. Penninx
  • Sara Pudas
  • Øystein Sørensen
  • Lídia Vaqué-Alcázar
  • Kristine B. Walhovd
  • Anders M. Fjell

Education has been related to various advantageous lifetime outcomes. Here, using longitudinal structural MRI data (4,422 observations), we tested the influential hypothesis that higher education translates into slower rates of brain aging. Cross-sectionally, education was modestly associated with regional cortical volume. However, despite marked mean atrophy in the cortex and hippocampus, education did not influence rates of change. The results were replicated across two independent samples. Our findings challenge the view that higher education slows brain aging.

OriginalsprogEngelsk
Artikelnummer2101644118
TidsskriftProceedings of the National Academy of Sciences of the United States of America
Vol/bind118
Udgave nummer18
ISSN0027-8424
DOI
StatusUdgivet - 2021

Bibliografisk note

Funding Information:
Lifespan Changes in Brain and Cognition—European Research Council under Grant Agreements 283634 and 725025 (to A.M.F.) and 313440 (to K.B.W.), as well as the Norwegian Research Council (to A.M.F. and K.B.W.); University of Barcelona—partial support by a Spanish Ministry of Science, Innovation and Universities (European Regional Development Fund; RTI2018-095181-B-C21) to D.B.-F., who was also supported by an Catalan Institution for Research and Advanced Studies Academia 2019 grant award; by the Walnuts and Healthy Aging study (http://www.clinicaltrials.gov; Grant NCT01634841) funded by the California Walnut Commission, Sacramento, CA; BASE-II—supported by the German Federal Ministry of Education and Research under Grants 16SV5537/ 16SV5837/16SV5538/16SV5536K/01UW0808/01UW0706/01GL1716A/01GL1716B. S.K. has received support from the European Research Council under Grant Agreement 677804; Cambridge Centre for Ageing and Neuroscience—initial funding from the Biotechnology and Biological Sciences Research Council, followed by support from the Medical Research Council Cognition and Brain Sciences Unit. Part of the research was conducted using the UK Biobank Resource under Application 32048.

Funding Information:
ACKNOWLEDGMENTS. This work was supported by European Union–Horizon 2020 Grant: “Healthy Minds 0–100 Years: Optimising the Use of European Brain Imaging Cohorts (‘Lifebrain’)” (Grant/Award 732592); Betula—a Scholar grant from the Knut and Alice Wallenberg Foundation (to L.N.); Center for

Publisher Copyright:
© 2021 National Academy of Sciences. All rights reserved.

ID: 304303023