fMRI in Parkinson’s Disease
Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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fMRI in Parkinson’s Disease. / Siebner, Hartwig R.; Meder, David; Herz, Damian M.
fMRI: Basics and Clinical Applications. red. / Stephan Ulmer; Olav Jansen. Springer Publishing Company, 2020. s. 417-431.Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt
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TY - CHAP
T1 - fMRI in Parkinson’s Disease
AU - Siebner, Hartwig R.
AU - Meder, David
AU - Herz, Damian M.
PY - 2020
Y1 - 2020
N2 - In this chapter, we review recent advances in functional magnetic resonance imaging (fMRI) in Parkinson’s disease (PD). Covariance patterns of regional resting-state activity in functional brain networks can be used to distinguish Parkinson patients from healthy controls and might play an important role as a biomarker in the future. Thee analyses of motor activity and connectivity have revealed compensatory mechanisms for impaired function of cortico-subcortical feedback loops and have shown how attentional mechanisms modulate the activity in motor loops. Other fMRI studies probing cognitive functions and reward-related behavior have shown that dopamine replacement can have detrimental effects on non-motor brain functions by altering physiological patterns of dopaminergic signaling. Neuroimaging can also be used to assess preclinical compensation of striatal dopaminergic denervation by studying asymptomatic carriers of mutations in genes that can cause PD. In conclusion, fMRI is a powerful tool to monitor changes in functional neural networks and has given important new insights into the pathophysiology of PD.
AB - In this chapter, we review recent advances in functional magnetic resonance imaging (fMRI) in Parkinson’s disease (PD). Covariance patterns of regional resting-state activity in functional brain networks can be used to distinguish Parkinson patients from healthy controls and might play an important role as a biomarker in the future. Thee analyses of motor activity and connectivity have revealed compensatory mechanisms for impaired function of cortico-subcortical feedback loops and have shown how attentional mechanisms modulate the activity in motor loops. Other fMRI studies probing cognitive functions and reward-related behavior have shown that dopamine replacement can have detrimental effects on non-motor brain functions by altering physiological patterns of dopaminergic signaling. Neuroimaging can also be used to assess preclinical compensation of striatal dopaminergic denervation by studying asymptomatic carriers of mutations in genes that can cause PD. In conclusion, fMRI is a powerful tool to monitor changes in functional neural networks and has given important new insights into the pathophysiology of PD.
U2 - 10.1007/978-3-030-41874-8_26
DO - 10.1007/978-3-030-41874-8_26
M3 - Book chapter
SN - 978-3-030-41873-1
SP - 417
EP - 431
BT - fMRI
A2 - Ulmer, Stephan
A2 - Jansen, Olav
PB - Springer Publishing Company
ER -
ID: 260249648