Maternal and early life iron intake and risk of childhood type 1 diabetes: A Danish case-cohort study
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Maternal and early life iron intake and risk of childhood type 1 diabetes : A Danish case-cohort study. / Thorsen, Steffen Ullitz; Halldorsson, Thorhallur I.; Bjerregaard, Anne A.; Olsen, Sjurdur F.; Svensson, Jannet.
I: Nutrients, Bind 11, Nr. 4, 734, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Maternal and early life iron intake and risk of childhood type 1 diabetes
T2 - A Danish case-cohort study
AU - Thorsen, Steffen Ullitz
AU - Halldorsson, Thorhallur I.
AU - Bjerregaard, Anne A.
AU - Olsen, Sjurdur F.
AU - Svensson, Jannet
PY - 2019
Y1 - 2019
N2 - Background: Iron overload has been associated with diabetes. Studies on iron exposure during pregnancy and in early life and risk of childhood type 1 diabetes (T1D) are sparse. We investigated whether iron supplementation during pregnancy and early in life were associated with risk of childhood T1D. Methods: In a case-cohort design, we identified up to 257 children with T1D (prevalence 0.37%) from the Danish National Birth Cohort through linkage with the Danish Childhood Diabetes Register. The primary exposure was maternal pure iron supplementation (yes/no) during pregnancy as reported in interview two at 30 weeks of gestation (n = 68,497 with iron supplement data). We estimated hazard ratios (HRs) using weighted Cox regression adjusting for multiple confounders. We also examined if offspring supplementation during the first 18 months of life was associated with later risk of T1D. Results: Maternal iron supplementation was not associated with later risk of T1D in the offspring HR 1.05 (95% CI: 0.76–1.45). Offspring intake of iron droplets during the first 18 months of life was inversely associated with risk of T1D HR 0.74 (95% CI: 0.55–1.00) (ptrend = 0.03). Conclusions: Our large-scale prospective study demonstrated no harmful effects of iron supplementation during pregnancy and in early life in regard to later risk of childhood T1D in the offspring.
AB - Background: Iron overload has been associated with diabetes. Studies on iron exposure during pregnancy and in early life and risk of childhood type 1 diabetes (T1D) are sparse. We investigated whether iron supplementation during pregnancy and early in life were associated with risk of childhood T1D. Methods: In a case-cohort design, we identified up to 257 children with T1D (prevalence 0.37%) from the Danish National Birth Cohort through linkage with the Danish Childhood Diabetes Register. The primary exposure was maternal pure iron supplementation (yes/no) during pregnancy as reported in interview two at 30 weeks of gestation (n = 68,497 with iron supplement data). We estimated hazard ratios (HRs) using weighted Cox regression adjusting for multiple confounders. We also examined if offspring supplementation during the first 18 months of life was associated with later risk of T1D. Results: Maternal iron supplementation was not associated with later risk of T1D in the offspring HR 1.05 (95% CI: 0.76–1.45). Offspring intake of iron droplets during the first 18 months of life was inversely associated with risk of T1D HR 0.74 (95% CI: 0.55–1.00) (ptrend = 0.03). Conclusions: Our large-scale prospective study demonstrated no harmful effects of iron supplementation during pregnancy and in early life in regard to later risk of childhood T1D in the offspring.
KW - Diabetes mellitus
KW - Fetal programming
KW - Infant
KW - Iron
KW - Newborn
KW - Pregnancy
KW - Type 1
U2 - 10.3390/nu11040734
DO - 10.3390/nu11040734
M3 - Journal article
C2 - 30934897
AN - SCOPUS:85064189347
VL - 11
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 4
M1 - 734
ER -
ID: 224184933