Introduction: In 2013, a new liver transplant allocation policy (Share 35) aimed to reduce waitlist-mortality was introduced in the United States. Regional organ sharing for recipients with a MELD score of ≥35 was prioritized over local allocation to those with lower MELD scores. Our aim was to assess the changes in perioperative mortality following the introduction of Share 35 as well as changes in patients’ short-term 7-day survival, patients discharged alive and 1-year survival. Analyses were also carried out for the subgroups of patients with MELD scores ≥ and < 35. Methods: We used data from the Scientific Registry of Transplant Recipients and included liver transplants between March 2002 and December 2018 in this retrospective cohort study. Perioperative mortality was defined as death during and within two days of liver transplant. We used robust interrupted time series analyses to evaluate the impact of Share 35 on mortality. Results: We included 90 002 liver transplants in our analysis and observed a decreasing trend in perioperative mortality over time (−.061 deaths per 1000 cases per month, 95% CI −.084 to −.037, p <.001). Share 35 was not associated with a change in perioperative mortality (p =.33), short-term 7-day survival (p =.48), survival to discharge (p =.56), or 1-year survival (p =.27). Conclusions: Prioritizing sicker recipients with a MELD score ≥35 for liver transplantation was not associated with a change in postoperative mortality.