Barrett's esophagus (BE) with dysplasia is generally accepted as the precursor to oesophageal cancer. Thus, methods to eradicate BE and dysplasia have been evaluated. Recently, radiofrequency ablation (RFA) has shown promising results with few adverse effects. The studies concerning RFA are, however, small and heterogeneous. Only six studies have included more than 100 patients and only one is a prospective randomized trial. The purpose of this article is to describe the treatment of BE and especially the indications and challenges of RFA, including complications, buried glands and recurrence.