Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study

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Standard

Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study. / Tetens, Malte M.; Omland, Lars Haukali; Dessau, Ram B.; Ellermann-Eriksen, Svend; Andersen, Nanna S.; Jørgensen, Charlotte Sværke; Østergaard, Christian; Bodilsen, Jacob; Søgaard, Kirstine K.; Bangsborg, Jette; Nielsen, Alex Christian; Møller, Jens Kjølseth; Chen, Ming; Svendsen, Jesper Hastrup; Obel, Niels; Lebech, Anne Mette.

I: Clinical Microbiology and Infection, Bind 30, Nr. 5, 2024, s. 621-629.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Tetens, MM, Omland, LH, Dessau, RB, Ellermann-Eriksen, S, Andersen, NS, Jørgensen, CS, Østergaard, C, Bodilsen, J, Søgaard, KK, Bangsborg, J, Nielsen, AC, Møller, JK, Chen, M, Svendsen, JH, Obel, N & Lebech, AM 2024, 'Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study', Clinical Microbiology and Infection, bind 30, nr. 5, s. 621-629. https://doi.org/10.1016/j.cmi.2024.01.024

APA

Tetens, M. M., Omland, L. H., Dessau, R. B., Ellermann-Eriksen, S., Andersen, N. S., Jørgensen, C. S., Østergaard, C., Bodilsen, J., Søgaard, K. K., Bangsborg, J., Nielsen, A. C., Møller, J. K., Chen, M., Svendsen, J. H., Obel, N., & Lebech, A. M. (2024). Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study. Clinical Microbiology and Infection, 30(5), 621-629. https://doi.org/10.1016/j.cmi.2024.01.024

Vancouver

Tetens MM, Omland LH, Dessau RB, Ellermann-Eriksen S, Andersen NS, Jørgensen CS o.a. Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study. Clinical Microbiology and Infection. 2024;30(5):621-629. https://doi.org/10.1016/j.cmi.2024.01.024

Author

Tetens, Malte M. ; Omland, Lars Haukali ; Dessau, Ram B. ; Ellermann-Eriksen, Svend ; Andersen, Nanna S. ; Jørgensen, Charlotte Sværke ; Østergaard, Christian ; Bodilsen, Jacob ; Søgaard, Kirstine K. ; Bangsborg, Jette ; Nielsen, Alex Christian ; Møller, Jens Kjølseth ; Chen, Ming ; Svendsen, Jesper Hastrup ; Obel, Niels ; Lebech, Anne Mette. / Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study. I: Clinical Microbiology and Infection. 2024 ; Bind 30, Nr. 5. s. 621-629.

Bibtex

@article{53783127b7044e13a7aaf5b6bf7ee0c5,
title = "Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study",
abstract = "Objectives: To investigate the short- and long-term risks of atrioventricular block and other cardiac conduction disorders associated with being tested for Borrelia burgdorferi (Bb) antibodies or Bb seropositivity as measures of confounding by indication and Bb infection, respectively. Methods: We performed a nationwide population-based matched cohort study (Denmark, 1993–2021). We included 52 200 Bb-seropositive individuals (stratified as only Bb-IgM-seropositive [n = 26 103], only Bb-IgG-seropositive [n = 18 698], and Bb-IgM-and-IgG-seropositive [n = 7399]) and two age- and sex-matched comparison cohorts: 104 400 Bb-seronegative individuals and 261 000 population controls. We investigated the risk associated with being tested for serum Bb antibodies and being Bb seropositive. Outcomes were atrioventricular block and other conduction disorders. We calculated short-term odds ratios (aOR) (within 1 month), and long-term hazard ratios (aHR) (after 1 month) adjusted for age, sex, diabetes, chronic heart failure, and kidney disease with 95% CI. Results: Compared with population controls, individuals tested for Bb antibodies had increased short- and long-term risks of atrioventricular block (aOR 47.9, 95% CI: 30.0–76.7, aHR 1.3, 95% CI:1.2–1.3), and other conduction disorders (aOR 18.2, 95% CI: 10.1–32.8, aHR 1.2, 95% CI: 1.1–1.4). Compared with Bb-seronegative individuals, only Bb-IgM-and-IgG-seropositive individuals had increased short-term risk of atrioventricular block (aOR: 2.1, 95% CI: 1.5–3.1). Discussion: The results suggest that Bb antibody testing is included in the diagnostic work-up of conduction disorders. Finally, that Bb seropositivity is not associated with other conduction disorders than atrioventricular block or with increased long-term risk of conduction disorders.",
keywords = "Atrioventricular block, Borrelia burgdorferi sensu lato, Borreliosis, Cardiac conduction system disease, Cohort study, Lyme disease, Serology",
author = "Tetens, {Malte M.} and Omland, {Lars Haukali} and Dessau, {Ram B.} and Svend Ellermann-Eriksen and Andersen, {Nanna S.} and J{\o}rgensen, {Charlotte Sv{\ae}rke} and Christian {\O}stergaard and Jacob Bodilsen and S{\o}gaard, {Kirstine K.} and Jette Bangsborg and Nielsen, {Alex Christian} and M{\o}ller, {Jens Kj{\o}lseth} and Ming Chen and Svendsen, {Jesper Hastrup} and Niels Obel and Lebech, {Anne Mette}",
note = "Funding Information: The study was funded by The Independent Research Fund Denmark, the Research Fund of Copenhagen University Hospital – Rigshospitalet, and the Lundbeck Foundation. Publisher Copyright: {\textcopyright} 2024 European Society of Clinical Microbiology and Infectious Diseases",
year = "2024",
doi = "10.1016/j.cmi.2024.01.024",
language = "English",
volume = "30",
pages = "621--629",
journal = "Clinical Microbiology and Infection",
issn = "1198-743X",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Risk of cardiac conduction disorders, and pacemaker implantations among individuals tested for serum Borrelia burgdorferi antibodies, a nationwide, matched, population-based cohort study

AU - Tetens, Malte M.

AU - Omland, Lars Haukali

AU - Dessau, Ram B.

AU - Ellermann-Eriksen, Svend

AU - Andersen, Nanna S.

AU - Jørgensen, Charlotte Sværke

AU - Østergaard, Christian

AU - Bodilsen, Jacob

AU - Søgaard, Kirstine K.

AU - Bangsborg, Jette

AU - Nielsen, Alex Christian

AU - Møller, Jens Kjølseth

AU - Chen, Ming

AU - Svendsen, Jesper Hastrup

AU - Obel, Niels

AU - Lebech, Anne Mette

N1 - Funding Information: The study was funded by The Independent Research Fund Denmark, the Research Fund of Copenhagen University Hospital – Rigshospitalet, and the Lundbeck Foundation. Publisher Copyright: © 2024 European Society of Clinical Microbiology and Infectious Diseases

PY - 2024

Y1 - 2024

N2 - Objectives: To investigate the short- and long-term risks of atrioventricular block and other cardiac conduction disorders associated with being tested for Borrelia burgdorferi (Bb) antibodies or Bb seropositivity as measures of confounding by indication and Bb infection, respectively. Methods: We performed a nationwide population-based matched cohort study (Denmark, 1993–2021). We included 52 200 Bb-seropositive individuals (stratified as only Bb-IgM-seropositive [n = 26 103], only Bb-IgG-seropositive [n = 18 698], and Bb-IgM-and-IgG-seropositive [n = 7399]) and two age- and sex-matched comparison cohorts: 104 400 Bb-seronegative individuals and 261 000 population controls. We investigated the risk associated with being tested for serum Bb antibodies and being Bb seropositive. Outcomes were atrioventricular block and other conduction disorders. We calculated short-term odds ratios (aOR) (within 1 month), and long-term hazard ratios (aHR) (after 1 month) adjusted for age, sex, diabetes, chronic heart failure, and kidney disease with 95% CI. Results: Compared with population controls, individuals tested for Bb antibodies had increased short- and long-term risks of atrioventricular block (aOR 47.9, 95% CI: 30.0–76.7, aHR 1.3, 95% CI:1.2–1.3), and other conduction disorders (aOR 18.2, 95% CI: 10.1–32.8, aHR 1.2, 95% CI: 1.1–1.4). Compared with Bb-seronegative individuals, only Bb-IgM-and-IgG-seropositive individuals had increased short-term risk of atrioventricular block (aOR: 2.1, 95% CI: 1.5–3.1). Discussion: The results suggest that Bb antibody testing is included in the diagnostic work-up of conduction disorders. Finally, that Bb seropositivity is not associated with other conduction disorders than atrioventricular block or with increased long-term risk of conduction disorders.

AB - Objectives: To investigate the short- and long-term risks of atrioventricular block and other cardiac conduction disorders associated with being tested for Borrelia burgdorferi (Bb) antibodies or Bb seropositivity as measures of confounding by indication and Bb infection, respectively. Methods: We performed a nationwide population-based matched cohort study (Denmark, 1993–2021). We included 52 200 Bb-seropositive individuals (stratified as only Bb-IgM-seropositive [n = 26 103], only Bb-IgG-seropositive [n = 18 698], and Bb-IgM-and-IgG-seropositive [n = 7399]) and two age- and sex-matched comparison cohorts: 104 400 Bb-seronegative individuals and 261 000 population controls. We investigated the risk associated with being tested for serum Bb antibodies and being Bb seropositive. Outcomes were atrioventricular block and other conduction disorders. We calculated short-term odds ratios (aOR) (within 1 month), and long-term hazard ratios (aHR) (after 1 month) adjusted for age, sex, diabetes, chronic heart failure, and kidney disease with 95% CI. Results: Compared with population controls, individuals tested for Bb antibodies had increased short- and long-term risks of atrioventricular block (aOR 47.9, 95% CI: 30.0–76.7, aHR 1.3, 95% CI:1.2–1.3), and other conduction disorders (aOR 18.2, 95% CI: 10.1–32.8, aHR 1.2, 95% CI: 1.1–1.4). Compared with Bb-seronegative individuals, only Bb-IgM-and-IgG-seropositive individuals had increased short-term risk of atrioventricular block (aOR: 2.1, 95% CI: 1.5–3.1). Discussion: The results suggest that Bb antibody testing is included in the diagnostic work-up of conduction disorders. Finally, that Bb seropositivity is not associated with other conduction disorders than atrioventricular block or with increased long-term risk of conduction disorders.

KW - Atrioventricular block

KW - Borrelia burgdorferi sensu lato

KW - Borreliosis

KW - Cardiac conduction system disease

KW - Cohort study

KW - Lyme disease

KW - Serology

U2 - 10.1016/j.cmi.2024.01.024

DO - 10.1016/j.cmi.2024.01.024

M3 - Journal article

C2 - 38316360

AN - SCOPUS:85186172193

VL - 30

SP - 621

EP - 629

JO - Clinical Microbiology and Infection

JF - Clinical Microbiology and Infection

SN - 1198-743X

IS - 5

ER -

ID: 388676388