TY - JOUR

T1 - Spinal cord involvement in multiple sclerosis and neuromyelitis optica spectrum disorders

AU - Ciccarelli, Olga

AU - Cohen, Jeffrey

AU - Reingold, Stephen

AU - Weinshenker, Brian G.

AU - Amato, Maria Pia

AU - Banwell, Brenda

AU - Barkhof, Frederik

AU - Bebo, Bruce

AU - Becher, Burkhard

AU - Bethoux, François

AU - Brandt, Alexander

AU - Brownlee, Wallace

AU - Calabresi, Peter

AU - Chatway, Jeremy

AU - Chien, Claudia

AU - Chitnis, Tanuja

AU - Cohen, Jeffrey

AU - Comi, Giancarlo

AU - Correale, Jorge

AU - De Sèze, Jerome

AU - De Stefano, Nicola

AU - Fazekas, Franz

AU - Flanagan, Eoin

AU - Freedman, Mark

AU - Fujihara, Kazuo

AU - Galetta, Steven

AU - Goldman, Myla

AU - Greenberg, Benjamin

AU - Hartung, Hans Peter

AU - Hemmer, Bernhard

AU - Henning, Anke

AU - Izbudak, Izlem

AU - Kappos, Ludwig

AU - Lassmann, Hans

AU - Laule, Cornelia

AU - Levy, Michael

AU - Lublin, Fred

AU - Lucchinetti, Claudia

AU - Lukas, Carsten

AU - Marrie, Ruth Ann

AU - Miller, Aaron

AU - Miller, David

AU - Montalban, Xavier

AU - Mowry, Ellen

AU - Ourselin, Sebastien

AU - Paul, Friedemann

AU - Pelletier, Daniel

AU - Ranjeva, Jean Philippe

AU - Reich, Daniel

AU - Soelberg Sorensen, Per

AU - International Conference on Spinal Cord Involvement and Imaging in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders

PY - 2019

Y1 - 2019

N2 - Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord imaging and poor correlation with disability megasures have impeded the understanding of the relationship between spinal cord involvement and clinical manifestations. Nevertheless, studies of the pathological features of multiple sclerosis and NMOSDs have shown that quantitatively different mechanisms lead to differences in clinical course and pattern of accrual of permanent disability in the two disorders. Better understanding of these mechanisms is necessary to develop more informative clinical measures, electrophysiological methods, fluid biomarkers, and imaging techniques to detect and monitor spinal cord involvement in the diagnosis and management of patients with multiple sclerosis or NMOSDs, and as outcome measures in clinical trials.

AB - Spinal cord involvement is an important cause of disability in patients with multiple sclerosis or neuromyelitis optica spectrum disorders (NMOSDs). Multiple sclerosis and NMOSDs can be distinguished from other disorders that cause myelopathy by results from laboratory and radiological investigations. However, limitations in the sensitivity and specificity of spinal cord imaging and poor correlation with disability megasures have impeded the understanding of the relationship between spinal cord involvement and clinical manifestations. Nevertheless, studies of the pathological features of multiple sclerosis and NMOSDs have shown that quantitatively different mechanisms lead to differences in clinical course and pattern of accrual of permanent disability in the two disorders. Better understanding of these mechanisms is necessary to develop more informative clinical measures, electrophysiological methods, fluid biomarkers, and imaging techniques to detect and monitor spinal cord involvement in the diagnosis and management of patients with multiple sclerosis or NMOSDs, and as outcome measures in clinical trials.

U2 - 10.1016/S1474-4422(18)30460-5

DO - 10.1016/S1474-4422(18)30460-5

M3 - Review

C2 - 30663608

AN - SCOPUS:85060049167

VL - 18

SP - 185

EP - 197

JO - The Lancet Neurology

JF - The Lancet Neurology

SN - 1474-4422

IS - 2

ER -