The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial
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BACKGROUND & AIM: Oxidized LDL (oxLDL) is a highly immunogenic particle that plays a key role in the development of atherosclerosis. Some data suggest a protective role of OxLDL autoantibodies (OLAB) in atherosclerosis. Our aim was to assess the effect of olive oil polyphenols on the immunogenicity of oxLDL to autoantibody generation. METHODS: In a crossover, controlled trial, 200 healthy men were randomly assigned to 3-week sequences of 25 mL/day of 3 olive oils with high (366 mg/kg), medium (164 mg/kg), and low (2.7 mg/kg) phenolic content. RESULTS: Plasma OLAB concentration was inversely associated with oxLDL (p
Originalsprog | Engelsk |
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Tidsskrift | Clinical Nutrition |
Vol/bind | 30 |
Udgave nummer | 4 |
Sider (fra-til) | 490-493 |
ISSN | 0261-5614 |
DOI | |
Status | Udgivet - 2 mar. 2011 |
ID: 34091061