The link between cognition and somatic conditions related to insulin resistance in the UK Biobank study cohort: a systematic review
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Clinical and genomic studies have shown an overlap between neuropsychiatric disorders and insulin resistance (IR)-related somatic conditions, including obesity, type 2 diabetes, and cardiovascular diseases. Impaired cognition is often observed among neuropsychiatric disorders, where multiple cognitive domains may be affected. In this review, we aimed to summarise previous evidence on the relationship between IR-related diseases/traits and cognitive performance in the large UK Biobank study cohort. Electronic searches were conducted on PubMed, Scopus, and Web of Science until April 2022. Eighteen articles met the inclusion criteria and were qualitatively reviewed. Overall, there is substantial evidence for an association between IR-related cardio-metabolic diseases/traits and worse performance on various cognitive domains, which is largely independent of possible confoundings. The most consistent findings referred to IR-related associations with poorer verbal and numerical reasoning ability, as well as slower processing speed. The observed associations might be mediated by alterations in immune-inflammation, brain integrity/connectivity, and/or comorbid somatic or psychiatric diseases/traits. Our findings provide impetus for further research into the underlying neurobiology and possible new therapeutic targets.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 104927 |
| Tidsskrift | Neuroscience and Biobehavioral Reviews |
| Vol/bind | 143 |
| ISSN | 0149-7634 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This work has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant agreement no. 847879 (PRIME, Prevention and Remediation of Insulin Multimorbidity in Europe). NRM was supported by the European Union’s Horizon 2020 research and innovation programme under Grant agreement no. 667302 (CoCA, Comorbid Conditions of ADHD) and by funding for the Dutch National Science Agenda NeurolabNL Project (Grant 400-17‐602). JSS is partially supported by the Catalan Institution for Research and Advanced Studies (ICREA) under the ICREA Academia programme. JB is supported by a personal grant from the Netherlands Organisation for Scientific Research (NWO) Innovation Program (Veni Grant no. 09150161910091). We also thank the authors of previous studies conducted using the UK Biobank cohort, and foremost, we thank all the individuals who agreed to be enroled in the UK Biobank cohort study.
Funding Information:
This work has received funding from the European Union's Horizon 2020 research and innovation programme under Grant agreement no. 847879 (PRIME, Prevention and Remediation of Insulin Multimorbidity in Europe). NRM was supported by the European Union's Horizon 2020 research and innovation programme under Grant agreement no. 667302 (CoCA, Comorbid Conditions of ADHD) and by funding for the Dutch National Science Agenda NeurolabNL Project (Grant 400-17‐602). JSS is partially supported by the Catalan Institution for Research and Advanced Studies (ICREA) under the ICREA Academia programme. JB is supported by a personal grant from the Netherlands Organisation for Scientific Research (NWO) Innovation Program (Veni Grant no. 09150161910091). We also thank the authors of previous studies conducted using the UK Biobank cohort, and foremost, we thank all the individuals who agreed to be enroled in the UK Biobank cohort study.
Publisher Copyright:
© 2022 The Authors
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