Use of 5-Aminolevulinic acid and daylight photodynamic therapy for the treatment of actinic keratoses
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Use of 5-Aminolevulinic acid and daylight photodynamic therapy for the treatment of actinic keratoses. / Shive, Melissa L.; Coakley, Brandon J.; Bierman, Dina F.; Serowka Lane, Kathryn L.; Wiegell, Stine R.; Haedersdal, Merete; Zachary, Christopher B.
I: Dermatologic Surgery, Bind 45, Nr. 4, 2019, s. 529-535.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Use of 5-Aminolevulinic acid and daylight photodynamic therapy for the treatment of actinic keratoses
AU - Shive, Melissa L.
AU - Coakley, Brandon J.
AU - Bierman, Dina F.
AU - Serowka Lane, Kathryn L.
AU - Wiegell, Stine R.
AU - Haedersdal, Merete
AU - Zachary, Christopher B.
PY - 2019
Y1 - 2019
N2 - BACKGROUNDPhotodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-Aminolevulinic acid (ALA).OBJECTIVETo study the safety and efficacy of D-PDT in treating AKs on the face and scalp using ALA.MATERIALS AND METHODSThirty patients were recruited for this prospective, uncontrolled study. Patients were treated with topical ALA on either the scalp or face, incubated for 30 minutes, and then sat at home in a shady area for 2 hours. Weather conditions, lux measurements, and AK counts at 3 and 6 months were measured.RESULTSDaylight PDT led to a median of 75% reduction in AK count at 6 months, with no significant adverse effects. Ninety-six percentage of patients were either moderately or very satisfied with the treatment, and the median peak pain score during treatment was 1. There was no correlation between weather or average lux received during treatment and 6-month outcomes.CONCLUSIONDaylight PDT with ALA is a safe and effective treatment modality for AKs on the head.
AB - BACKGROUNDPhotodynamic therapy (PDT) is an effective modality for the treatment of actinic keratoses (AKs). The use of methyl aminolevulinate with daylight PDT (D-PDT) has quickly gained popularity internationally because of its tolerability and high levels of safety and efficacy. However, there is a paucity of studies on the use of D-PDT with 5-Aminolevulinic acid (ALA).OBJECTIVETo study the safety and efficacy of D-PDT in treating AKs on the face and scalp using ALA.MATERIALS AND METHODSThirty patients were recruited for this prospective, uncontrolled study. Patients were treated with topical ALA on either the scalp or face, incubated for 30 minutes, and then sat at home in a shady area for 2 hours. Weather conditions, lux measurements, and AK counts at 3 and 6 months were measured.RESULTSDaylight PDT led to a median of 75% reduction in AK count at 6 months, with no significant adverse effects. Ninety-six percentage of patients were either moderately or very satisfied with the treatment, and the median peak pain score during treatment was 1. There was no correlation between weather or average lux received during treatment and 6-month outcomes.CONCLUSIONDaylight PDT with ALA is a safe and effective treatment modality for AKs on the head.
U2 - 10.1097/DSS.0000000000001771
DO - 10.1097/DSS.0000000000001771
M3 - Journal article
C2 - 30807390
AN - SCOPUS:85064239346
VL - 45
SP - 529
EP - 535
JO - Dermatologic Surgery
JF - Dermatologic Surgery
SN - 1076-0512
IS - 4
ER -
ID: 241370223