1型糖尿病儿童的乳糜泻在世界各地各不相同:一项对来自SWEET注册中心的57375名患者进行的国际横断面研究
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: Children with type 1 diabetes (T1D) are at much higher risk of developing celiac disease (CD) than the general population. The aim of the study was to assess the prevalence and differences in clinical presentation of CD in T1D in different regions of the world. Methods: This study is based on the Better control in Pediatric and Adolescent diabeteS: Working to crEate cEnTers of Reference (SWEET) database. There were 57 375 patients included in the study, aged ≤18 years from 54 SWEET centers. Only centers with screening for celiac disease were included. Regression models adjusted for age, diabetes duration, and gender and a fixed effect in the models for region was used. Diabetes duration, age at diabetes onset, and sex were presented as unadjusted results. Results: CD was present in 2652 subjects (4.5%), with different prevalence among regions: from 1.9% in Asia/Middle East to 6.9% in Australia/New Zealand. CD was observed more often among females. Comparing children with and without CD, characteristics for those with CD were younger age at diabetes onset (6.3 [3.3; 9.8] vs 8.1 [4.6; 11.3], P < 0.001) and had longer diabetes duration (6.4 [3.6; 9.8] vs 4.8 [2.1; 8.2], P < 0.001). Further, they had lower glycosylated hemoglobin (HbA1c) in Europe and North America/Canada; lower body mass index (BMI)-SD score (BMI-SDS) in southern Europe, North America, and Canada; In most regions daily insulin dose was lower, height-SDS was lower, and the percentage of insulin pump users was higher in children with T1D and CD. Conclusions: The prevalence and the anthropometric and metabolic consequences of CD in children with T1D differ around the world.
| Bidragets oversatte titel | Celiac disease in children with type 1 diabetes varies around the world: An international, cross-sectional study of 57 375 patients from the SWEET registry |
|---|---|
| Originalsprog | Kinesisk (Traditional) |
| Tidsskrift | Journal of Diabetes |
| Vol/bind | 13 |
| Udgave nummer | 6 |
| Sider (fra-til) | 448-457 |
| Antal sider | 10 |
| ISSN | 1753-0393 |
| DOI | |
| Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
We thank the following for their support of this work: Katharina Fink and Anke Schwandt for the data management as well as Andreas Hungele and Ramona Ranz for the DPV software (all Ulm University, Germany), Michael Witsch (Centre Hospitalier de Luxembourg, Luxembourg) for center integration, Thomas Danne and Olga Kordonouri (Kinderkrankenhaus Auf der Bult, Hannover, Germany) for initiating the SWEET collaboration, Ines Hiller, Katharina Klee (Kinderkrankenhaus Auf der Bult, Hannover, Germany) and Reinhard Holl (Ulm University, Germany) for their invaluable support. Finally, we would like to thank all participating centers of the SWEET network, especially the collaborating centers in this investigation. This work was supported by the SWEET corporate members: Abbott, Boehringer Ingelheim, Dexcom, Insulet, Lilly, Medtronic, and Sanofi. The content is solely the responsibility of the authors and does not necessarily represent the official views of the corporate members.
Funding Information:
We thank the following for their support of this work: Katharina Fink and Anke Schwandt for the data management as well as Andreas Hungele and Ramona Ranz for the DPV software (all Ulm University, Germany), Michael Witsch (Centre Hospitalier de Luxembourg, Luxembourg) for center integration, Thomas Danne and Olga Kordonouri (Kinderkrankenhaus Auf der Bult, Hannover, Germany) for initiating the SWEET collaboration, Ines Hiller, Katharina Klee (Kinderkrankenhaus Auf der Bult, Hannover, Germany) and Reinhard Holl (Ulm University, Germany) for their invaluable support. Finally, we would like to thank all participating centers of the SWEET network, especially the collaborating centers in this investigation. This work was supported by the SWEET corporate members: Abbott, Boehringer Ingelheim, Dexcom, Insulet, Lilly, Medtronic, and Sanofi. The content is solely the responsibility of the authors and does not necessarily represent the official views of the corporate members.
Publisher Copyright:
© 2020 Ruijin Hospital, Shanghai JiaoTong University School of Medicine and John Wiley & Sons Australia, Ltd
- celiac disease, international database, SWEET, type 1 diabetes
Forskningsområder
ID: 301139758