Anxiety, mood, and substance use disorders in adult men and women with and without attention-deficit/hyperactivity disorder: A substantive and methodological overview

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

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  • Catharina A. Hartman
  • Henrik Larsson
  • Melissa Vos
  • Alessio Bellato
  • Berit Libutzki
  • Berit Skretting Solberg
  • Qi Chen
  • Ebba Du Rietz
  • Jeanette C. Mostert
  • Sarah Kittel-Schneider
  • Bru Cormand
  • Marta Ribasés
  • Kari Klungsøyr
  • Jan Haavik
  • Dalsgaard, Søren
  • Samuele Cortese
  • Stephen V. Faraone
  • Andreas Reif

Knowledge on psychiatric comorbidity in adult ADHD is essential for prevention, detection, and treatment of these conditions. This review (1) focuses on large studies (n > 10,000; surveys, claims data, population registries) to identify (a) overall, (b) sex- and (c) age-specific patterns of comorbidity of anxiety disorders (ADs), major depressive disorder (MDD), bipolar disorder (BD) and substance use disorders (SUDs) in adults with ADHD relative to adults without ADHD; and (2) describes methodological challenges relating to establishing comorbidity in ADHD in adults as well as priorities for future research. Meta-analyses (ADHD: n = 550,748; no ADHD n = 14,546,814) yielded pooled odds ratios of 5.0(CI:3.29–7.46) for ADs, 4.5(CI:2.44–8.34) for MDD, 8.7(CI:5.47–13.89) for BD and 4.6(CI:2.72–7.80) for SUDs, indicating strong differences in adults with compared to adults without ADHD. Moderation by sex was not found: high comorbidity held for both men and women with sex-specific patterns as in the general population: higher prevalences of ADs, MDD and BD in women and a higher prevalence of SUDs in men. Insufficient data on different phases of the adult lifespan prevented conclusions on developmental changes in comorbidity. We discuss methodological challenges, knowledge gaps, and future research priorities.

OriginalsprogEngelsk
Artikelnummer105209
TidsskriftNeuroscience and Biobehavioral Reviews
Vol/bind151
Antal sider18
ISSN0149-7634
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
This research has received funding from the EU's Horizon 2020 Research and Innovation Program under grant agreements 667302 (CoCA), 728018 (Eat2beNICE) and 965381(TIMESPAN) and from the 'ECNP network on ADHD across the lifespan'. BC was supported by the Spanish ‘Ministerio de Ciencia, Innovación y Universidades’ (PID2021-1277760B-I100), ‘Generalitat de Catalunya/AGAUR’ (2021-SGR-01093), ICREA Academia 2021, the European Union H2020 Program [H2020/2014-2020] under grant agreement 728018 (Eat2beNICE), ‘Fundació La Marató de TV3’ (202218-31) and the 'ECNP network of ADHD across the lifespan'. SF's research is supported by NIMH grants U01MH109536-01, U01AR076092-01A1, R0MH116037 and 5R01AG06495502.

Funding Information:
This research has received funding from the EU’s Horizon 2020 Research and Innovation Program under grant agreements 667302 (CoCA), 728018 (Eat2beNICE) and 965381 (TIMESPAN) and from the 'ECNP network on ADHD across the lifespan'. BC was supported by the Spanish ‘Ministerio de Ciencia , Innovación y Universidades’ ( PID2021-1277760B-I100 ), ‘ Generalitat de Catalunya/AGAUR ’ ( 2021-SGR-01093 ), ICREA Academia 2021, the European Union H2020 Program [ H2020/2014-2020 ] under grant agreement 728018 (Eat2beNICE), ‘ Fundació La Marató de TV3 ’ ( 202218-31 ) and the 'ECNP network of ADHD across the lifespan'. SF’s research is supported by NIMH grants U01MH109536-01 , U01AR076092-01A1 , R0MH116037 and 5R01AG06495502 .

Publisher Copyright:
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