Association of intraosseous and intravenous access with patient outcome in out-of-hospital cardiac arrest

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  • Frederik Nancke Nilsson
  • Søren Bie-Bogh
  • Louise Milling
  • Peter Martin Hansen
  • Helena Pedersen
  • Erika F. Christensen
  • Jens Stubager Knudsen
  • Christensen, Helle Collatz
  • Folke, Fredrik
  • David Høen-Beck
  • Ulla Væggemose
  • Anne Craveiro Brøchner
  • Søren Mikkelsen
Here we report the results of a study on the association between drug delivery via intravenous route or intraosseous route in out-of-hospital cardiac arrest. Intraosseous drug delivery is considered an alternative option in resuscitation if intravenous access is difficult or impossible. Intraosseous uptake of drugs may, however, be compromised. We have performed a retrospective cohort study of all Danish patients with out-of-hospital cardiac arrest in the years 2016–2020 to investigate whether mortality is associated with the route of drug delivery. Outcome was 30-day mortality, death at the scene, no prehospital return of spontaneous circulation, and 7- and 90-days mortality. 17,250 patients had out-of-hospital cardiac arrest. 6243 patients received no treatment and were excluded. 1908 patients had sustained return of spontaneous circulation before access to the vascular bed was obtained. 2061 patients were unidentified, and 286 cases were erroneously registered. Thus, this report consist of results from 6752 patients. Drug delivery by intraosseous route is associated with increased OR of: No spontaneous circulation at any time (OR 1.51), Death at 7 days (OR 1.94), 30 days (2.02), and 90 days (OR 2.29). Intraosseous drug delivery in out-of-hospital cardiac arrest is associated with overall poorer outcomes than intravenous drug delivery.
TidsskriftScientific Reports
Udgave nummer1
Antal sider7
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
This study was funded by the Danish Air Ambulance who had no role in planning, data collection, interpretation of data nor writing of this paper.

Publisher Copyright:
© 2023, The Author(s).

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