Asthma medication and risk of dental diseases in children – A prospective cohort study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Dental caries and enamel defects are the main causes of poor dental health in children, with a substantial impact on their well-being. Use of inhaled asthma medication is a suspected risk factor, but there is a lack of prospective studies investigating this and other prenatal and early life risk factors.
Methods
Copenhagen Prospective Studies on Asthma in Childhood 2010 mother–child cohort (COPSAC2010) consists of 700 women who were recruited at 24 weeks of pregnancy. 588 of their children participated in a dental examination at 6 years of age (84%) at the COPSAC2010 research unit. Caries was defined as decayed, missing, or filled surfaces. Enamel defect was defined as demarcated opacity, post-eruptive enamel breakdown, and/or atypical restoration on at least one molar. Caries and enamel defects were assessed in both deciduous and permanent dentitions.
Results
We found no associations between inhaled corticosteroids or β2-agonists or asthma symptoms in early childhood and the risk of caries or enamel defects by 6 years of age. Furthermore, we found no strong pre-, peri-, or postnatal risk factors for dental diseases at 6 years, except from nominally significant associations between antibiotic use in pregnancy (OR = 1.25, [1.01–1.54]), maternal education level (OR = 1.57, [1.01–2.45]), having a dog at home (OR = 0.50, [0.27–0.93]), and risk of enamel defects.
Conclusions
Use of inhaled corticosteroids, β2-agonists, or asthma symptoms in the first 6 years of life were not associated with the development of caries or enamel defects. This finding is reassuring for parents and physicians prescribing asthma medication for young children.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | e14026 |
| Tidsskrift | Pediatric Allergy and Immunology |
| Vol/bind | 34 |
| Udgave nummer | 10 |
| Antal sider | 11 |
| ISSN | 0905-6157 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We express our deepest gratitude to the children and families of the COPSAC2010 cohort study for all their support and commitment. We acknowledge and appreciate the unique efforts of the COPSAC research team. All co-authors have contributed substantially to the analyses and/or interpretation of the data and have provided important intellectual input and approval of the final version of the manuscript. No honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Hans Bisgaard had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Pia Elisabeth Nørrisgaard and Klaus Bønnelykke drafted the manuscript. All authors critically revised the manuscript for important intellectual content. Pia Elisabeth Nørrisgaard and Klaus Bønnelykke made the statistical analysis. Jan Kühnisch scored the reliability of the dental registrations, and the validation was performed at the Department of Conservative Dentistry and Periodontology, School of Dentistry, University of Munich. We are aware of and comply with recognized codes of good research practice, including the Danish Code of Conduct for Research Integrity. We comply with national and international rules on the safety and rights of patients and healthy subjects, including Good Clinical Practice (GCP) as defined in the EU's Directive on Good Clinical Practice, the International Conference on Harmonization's (ICH) good clinical practice guidelines and the Helsinki Declaration. We follow national and international rules on the processing of personal data, including the Danish Act on Processing of Personal Data and the practice of the Danish Data Inspectorate.
Publisher Copyright:
© 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
ID: 375795373