Comparison of PSA density and lesion volume strategies for selecting men with equivocal PI-RADS 3 lesions on bpMRI for biopsies
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Purpose: To compare two strategies: Prostate-specific antigen density (PSAd) and lesion volume measurement in ruling out significant prostate cancer (sPCa) in men with equivocal Prostate Imaging Reporting and Data System (PI-RADS) category 3 index lesions on biparametric magnetic resonance imaging. Methods: In total, 130 men from our database had index lesions with PI-RADS scores of 3. Prostate volume was measured using the ellipsoid method, in accordance with PI-RADS version 2.1 criteria. Index lesion volumes were also measured using the ellipsoidal formula on the diffusion-weighted imaging sequence with the highest b-value and sagittal T2 sequences. Results: Among 130 men with PI-RADS category 3 index lesions, 23 (18%) had sPCa. In total, 6 of the 89 men with PSAd < 0.15 ng/mL2 (7%) had sPCa, whereas 8 of the 49 men with index lesion volumes < 0.5 mL (16%) had sPCa. The difference was statistically significant (McNemar, p < 0.0001). Conclusion: The PSAd strategy performed better than the lesion volume strategy in ruling out sPCa in men with equivocal PI-RADS category 3 index lesions.
Originalsprog | Engelsk |
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Tidsskrift | Abdominal Radiology |
Vol/bind | 48 |
Udgave nummer | 2 |
Sider (fra-til) | 688-693 |
Antal sider | 6 |
ISSN | 2366-004X |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The authors received financial support from the Master Carpenter Jørgen Holm and wife Elisa F. Hansen’s memorial scholarship (20009).
Publisher Copyright:
© 2022, The Author(s).
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