Continuous long-term heart rate variability and risk assessment in pulmonary hypertension

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Objective Current multimodal risk assessment for pulmonary hypertension (PH) has been redefined with a simplified assessment for follow-up in the new European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines. Follow-up risk assessment parameters include WHO functional class, 6 min walk test and N-terminal pro-brain natriuretic peptide. Although these parameters have prognostic implications assessment reflect data relating to specific time points. Methods Patients diagnosed with PH received an implantable loop recorder (ILR) to monitor daytime and night-time heart rate (HR), HR variability (HRV) and daily physical activity. Associations between the ILR measurements and established risk parameters were analysed using correlations, linear mixed models as well as logistical mixed models for addressing the ESC/ERS risk-score. Results 41 patients (median age: 56 years, range: 44-61.5 years) were included. Continuous monitoring had a median duration of 755 days (range: 343-1138 days), totalling 96 patient-years. In the linear mixed models, HRV and physical activity indexed by daytime HR (PAiHR) were significantly associated with the ERS/ERC risk parameters. In a logistical mixed model, HRV revealed a significant difference between 1-year mortality (<5% vs >5%) (p=0.027) with an OR of 0.82 for being in the group with 1-year mortality >5% for every increase by one HRV unit. Conclusions Risk assessment in PH can be refined with continuous monitoring of HRV and PAiHR. These markers were associated with the ESC/ERC parameters. Our study with continuous risk stratification in PH demonstrated that a lower HRV predict worse prognosis.

OriginalsprogEngelsk
Artikelnummere002302
TidsskriftOpen Heart
Vol/bind10
Udgave nummer1
Antal sider8
ISSN2398-595X
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
The study was supported by the Heart Centre Research Council of Rigshospitalet and an investigator-initiated study research grant from Janssen-Cilag. It was conducted without any interference or financial support from the manufacturer of the ILR used.

Funding Information:
SZD has received consultancy fees from Bristol Myers Squibb/Pfizer, Vital Beats and Acesion Pharma, speaker fees from Bristol Myers Squibb, and travel grants from Abbott. JHS is a member of an advisory board for Medtronic and have received speaker fees and research grants from Medtronic. JC is a member of an advisory board for Janssen-Cilag and has received institutional research grants and speaker fees.

Publisher Copyright:
© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

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