Early experience in avoiding biopsies for biopsy-naive men with clinical suspicion of prostate cancer but non-suspicious biparametric magnetic resonance imaging results and prostate-specific antigen density < 0.15 ng/mL2: A 2-year follow-up study
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Early experience in avoiding biopsies for biopsy-naive men with clinical suspicion of prostate cancer but non-suspicious biparametric magnetic resonance imaging results and prostate-specific antigen density < 0.15 ng/mL2 : A 2-year follow-up study. / Kortenbach, Karen-Cecilie; Logager, Vibeke; Thomsen, Henrik S.; Boesen, Lars.
I: Acta Radiologica Open, Bind 11, Nr. 4, 20584601221094825, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Early experience in avoiding biopsies for biopsy-naive men with clinical suspicion of prostate cancer but non-suspicious biparametric magnetic resonance imaging results and prostate-specific antigen density < 0.15 ng/mL2
T2 - A 2-year follow-up study
AU - Kortenbach, Karen-Cecilie
AU - Logager, Vibeke
AU - Thomsen, Henrik S.
AU - Boesen, Lars
PY - 2022
Y1 - 2022
N2 - Background: Only limited data have been published on the diagnostic accuracy of combining biparametric (bp) magnetic resonance imaging (MRI) and prostate-specific antigen density (PSAd) to rule out biopsies.Purpose: The purpose is to assess the 2-year risk of being diagnosed with sPCa following the strategy of avoiding immediate biopsies in men with non-suspicious bp MRIs and a PSAdMaterial and Methods: Two hundred biopsy-naive men with clinical suspicion of PCa underwent a pre-biopsy bp MRI from March to July 2019. Of these, 109 men had a Prostate Imaging Reporting and Data System (PI-RADS) score of 1-3 including 77 men with calculated PSAd = 0.15 ng/mL(2) underwent systematic biopsies and targeted biopsies of any PI-RADS 3 lesion.Results: One of the 77 men (1.3%) had an sPCa diagnosed within 2 years of follow-up. All men were referred back to their general practitioner within 1 year and 9% (7/77) were re-referred to the urology department during follow-up. Among these men, 43% (3/7) continued to have PSA levels that were above their individual thresholds at confirmatory testing and underwent secondary MRI scans.Conclusions: No biopsies for men with bpMRI results exhibiting maximum PI-RADS 3 and with a PSAd
AB - Background: Only limited data have been published on the diagnostic accuracy of combining biparametric (bp) magnetic resonance imaging (MRI) and prostate-specific antigen density (PSAd) to rule out biopsies.Purpose: The purpose is to assess the 2-year risk of being diagnosed with sPCa following the strategy of avoiding immediate biopsies in men with non-suspicious bp MRIs and a PSAdMaterial and Methods: Two hundred biopsy-naive men with clinical suspicion of PCa underwent a pre-biopsy bp MRI from March to July 2019. Of these, 109 men had a Prostate Imaging Reporting and Data System (PI-RADS) score of 1-3 including 77 men with calculated PSAd = 0.15 ng/mL(2) underwent systematic biopsies and targeted biopsies of any PI-RADS 3 lesion.Results: One of the 77 men (1.3%) had an sPCa diagnosed within 2 years of follow-up. All men were referred back to their general practitioner within 1 year and 9% (7/77) were re-referred to the urology department during follow-up. Among these men, 43% (3/7) continued to have PSA levels that were above their individual thresholds at confirmatory testing and underwent secondary MRI scans.Conclusions: No biopsies for men with bpMRI results exhibiting maximum PI-RADS 3 and with a PSAd
KW - Biomarkers
KW - biparametric magnetic resonance imaging
KW - diagnostic imaging
KW - magnetic resonance imaging
KW - outcome assessment
KW - prostate cancer
KW - ISUP CONSENSUS CONFERENCE
KW - INTERNATIONAL-SOCIETY
KW - COMPLICATIONS
KW - ASSOCIATION
KW - DIAGNOSIS
KW - MRI
U2 - 10.1177/20584601221094825
DO - 10.1177/20584601221094825
M3 - Journal article
VL - 11
JO - Acta Radiologica Short Reports
JF - Acta Radiologica Short Reports
SN - 2047-9816
IS - 4
M1 - 20584601221094825
ER -
ID: 345019349