Exercise and health — emerging roles of IL-6
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Skeletal muscle works as a secretory organ with the capacity to produce hundreds of myokines. This finding provides a conceptual basis for understanding how muscles communicate with other organs such as adipose tissue, liver, pancreas, bones, and brain. The myokine IL-6 is released into the blood during exercise and it has been shown that IL-6 has multiple immunologic and metabolic effects. Here, we discuss recent advances regarding the physiology of IL-6. Human studies show that IL-6 infusion delays gastric emptying, reduces postprandial glucose concentrations and reduces insulin secretion, whereas experimental studies suggest a role for IL-6 in appetite regulation. Evidence is also accumulating for a central role of IL-6 in training-induced loss of visceral adipose tissue mass in humans. Moreover, recent experimental studies in mice show that voluntary exercise suppresses tumor growth through epinephrine-dependent and IL-6-dependent mobilization and redistribution of cytotoxic NK cells. It has been known for a while that IL-6 is a pleiotropic molecule; however, recent advances suggest that the physiological roles of IL-6 involve multiple aspects of metabolism as well as a role in tumor defense.
Originalsprog | Engelsk |
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Tidsskrift | Current Opinion in Physiology |
Vol/bind | 10 |
Sider (fra-til) | 49-54 |
Antal sider | 6 |
ISSN | 2468-8681 |
DOI | |
Status | Udgivet - 2019 |
ID: 241160939