Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix. / Nigro, Pasquale; Vamvini, Maria; Yang, Jiekun; Caputo, Tiziana; Ho, Li Lun; Carbone, Nicholas P.; Papadopoulos, Danae; Conlin, Royce; He, Jie; Hirshman, Michael F.; White, Joseph D.; Robidoux, Jacques; Hickner, Robert C.; Nielsen, Søren; Pedersen, Bente K.; Kellis, Manolis; Middelbeek, Roeland J.W.; Goodyear, Laurie J.

I: Cell Reports, Bind 42, Nr. 4, 112392, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nigro, P, Vamvini, M, Yang, J, Caputo, T, Ho, LL, Carbone, NP, Papadopoulos, D, Conlin, R, He, J, Hirshman, MF, White, JD, Robidoux, J, Hickner, RC, Nielsen, S, Pedersen, BK, Kellis, M, Middelbeek, RJW & Goodyear, LJ 2023, 'Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix', Cell Reports, bind 42, nr. 4, 112392. https://doi.org/10.1016/j.celrep.2023.112392

APA

Nigro, P., Vamvini, M., Yang, J., Caputo, T., Ho, L. L., Carbone, N. P., Papadopoulos, D., Conlin, R., He, J., Hirshman, M. F., White, J. D., Robidoux, J., Hickner, R. C., Nielsen, S., Pedersen, B. K., Kellis, M., Middelbeek, R. J. W., & Goodyear, L. J. (2023). Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix. Cell Reports, 42(4), [112392]. https://doi.org/10.1016/j.celrep.2023.112392

Vancouver

Nigro P, Vamvini M, Yang J, Caputo T, Ho LL, Carbone NP o.a. Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix. Cell Reports. 2023;42(4). 112392. https://doi.org/10.1016/j.celrep.2023.112392

Author

Nigro, Pasquale ; Vamvini, Maria ; Yang, Jiekun ; Caputo, Tiziana ; Ho, Li Lun ; Carbone, Nicholas P. ; Papadopoulos, Danae ; Conlin, Royce ; He, Jie ; Hirshman, Michael F. ; White, Joseph D. ; Robidoux, Jacques ; Hickner, Robert C. ; Nielsen, Søren ; Pedersen, Bente K. ; Kellis, Manolis ; Middelbeek, Roeland J.W. ; Goodyear, Laurie J. / Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix. I: Cell Reports. 2023 ; Bind 42, Nr. 4.

Bibtex

@article{cb9df2d621a547dbaf6aeb9b70bdf9ef,
title = "Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix",
abstract = "Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise training results in a more favorable iWAT structural phenotype. Using biochemical, imaging, and multi-omics analyses, we find that 11 days of wheel running in male mice causes profound iWAT remodeling including decreased extracellular matrix (ECM) deposition and increased vascularization and innervation. We identify adipose stem cells as one of the main contributors to training-induced ECM remodeling, show that the PRDM16 transcriptional complex is necessary for iWAT remodeling and beiging, and discover neuronal growth regulator 1 (NEGR1) as a link between PRDM16 and neuritogenesis. Moreover, we find that training causes a shift from hypertrophic to insulin-sensitive adipocyte subpopulations. Exercise training leads to remarkable adaptations to iWAT structure and cell-type composition that can confer beneficial changes in tissue metabolism.",
keywords = "Adipo-Clear, CP: Metabolism, CP: Molecular biology, ECM, exercise, innervation, NEGR1, PRDM16, proteomics, spatial transcriptomics, vascularization, white adipose tissue",
author = "Pasquale Nigro and Maria Vamvini and Jiekun Yang and Tiziana Caputo and Ho, {Li Lun} and Carbone, {Nicholas P.} and Danae Papadopoulos and Royce Conlin and Jie He and Hirshman, {Michael F.} and White, {Joseph D.} and Jacques Robidoux and Hickner, {Robert C.} and S{\o}ren Nielsen and Pedersen, {Bente K.} and Manolis Kellis and Middelbeek, {Roeland J.W.} and Goodyear, {Laurie J.}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.celrep.2023.112392",
language = "English",
volume = "42",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "4",

}

RIS

TY - JOUR

T1 - Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix

AU - Nigro, Pasquale

AU - Vamvini, Maria

AU - Yang, Jiekun

AU - Caputo, Tiziana

AU - Ho, Li Lun

AU - Carbone, Nicholas P.

AU - Papadopoulos, Danae

AU - Conlin, Royce

AU - He, Jie

AU - Hirshman, Michael F.

AU - White, Joseph D.

AU - Robidoux, Jacques

AU - Hickner, Robert C.

AU - Nielsen, Søren

AU - Pedersen, Bente K.

AU - Kellis, Manolis

AU - Middelbeek, Roeland J.W.

AU - Goodyear, Laurie J.

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise training results in a more favorable iWAT structural phenotype. Using biochemical, imaging, and multi-omics analyses, we find that 11 days of wheel running in male mice causes profound iWAT remodeling including decreased extracellular matrix (ECM) deposition and increased vascularization and innervation. We identify adipose stem cells as one of the main contributors to training-induced ECM remodeling, show that the PRDM16 transcriptional complex is necessary for iWAT remodeling and beiging, and discover neuronal growth regulator 1 (NEGR1) as a link between PRDM16 and neuritogenesis. Moreover, we find that training causes a shift from hypertrophic to insulin-sensitive adipocyte subpopulations. Exercise training leads to remarkable adaptations to iWAT structure and cell-type composition that can confer beneficial changes in tissue metabolism.

AB - Inguinal white adipose tissue (iWAT) is essential for the beneficial effects of exercise training on metabolic health. The underlying mechanisms for these effects are not fully understood, and here, we test the hypothesis that exercise training results in a more favorable iWAT structural phenotype. Using biochemical, imaging, and multi-omics analyses, we find that 11 days of wheel running in male mice causes profound iWAT remodeling including decreased extracellular matrix (ECM) deposition and increased vascularization and innervation. We identify adipose stem cells as one of the main contributors to training-induced ECM remodeling, show that the PRDM16 transcriptional complex is necessary for iWAT remodeling and beiging, and discover neuronal growth regulator 1 (NEGR1) as a link between PRDM16 and neuritogenesis. Moreover, we find that training causes a shift from hypertrophic to insulin-sensitive adipocyte subpopulations. Exercise training leads to remarkable adaptations to iWAT structure and cell-type composition that can confer beneficial changes in tissue metabolism.

KW - Adipo-Clear

KW - CP: Metabolism

KW - CP: Molecular biology

KW - ECM

KW - exercise

KW - innervation

KW - NEGR1

KW - PRDM16

KW - proteomics

KW - spatial transcriptomics

KW - vascularization

KW - white adipose tissue

U2 - 10.1016/j.celrep.2023.112392

DO - 10.1016/j.celrep.2023.112392

M3 - Journal article

C2 - 37058410

AN - SCOPUS:85152296501

VL - 42

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 4

M1 - 112392

ER -

ID: 362891079