Infectious diseases are major health care challenges globally and a prevalent cause of admission to emergency departments.Epidemiologic characteristics and outcomes based on population level data are limited. The Database of Community AcquiredInfections in Eastern Denmark (DCAIED) 2018–2021 was established with the aim to explore and estimate the populationcharacteristics, and outcomes of patients suffering from community acquired infections at the emergency departments in the CapitalRegion and the Zealand Region of Denmark using data from electronic medical records. Adult patients (≥18 years) presenting to theemergency department with suspected or confirmed infection are included in the cohort. Presence of sepsis and organ failure areassessed using modified criteria from the Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). During theinclusion period from January 2018 to January 2022, 2,241,652 adult emergency department visits have been registered. Of these,451,825 were unique encounters of which 60,316 fulfilled criteria of suspected infection and 28,472 fulfilled sepsis criteria and 8,027were defined as septic shock. The database covers the entire Capital and Zealand Region of Denmark with an uptake area of2.6 million inhabitants and includes demographic, laboratory and outcome indicators, with complete follow-up. The database is well-suited for epidemiological research for future national and international collaborations.