Geographical variation in the incidence of type 1 diabetes in the Nordic countries: A study within NordicDiabKids

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Dokumenter

  • Ulf Samuelsson
  • Lars Westerberg
  • Karin Aakesson
  • Niels H. Birkebæk
  • Ragnar Bjarnason
  • Ann K. Drivvoll
  • Torild Skrivarhaug
  • Svensson, Jannet
  • Arni Thorsson
  • Lena Hanberger
  • Nordic Childhood Diabetes Registry Study Group, NordicDiabKids

Background: The incidence of type 1 diabetes (T1D) is high in the Nordic countries with geographic differences between as well as within countries. Objective: To describe the geographical distribution of the incidence of T1D among children in four Nordic countries, an area where the population is considered genetically similar. Methods: Data on children 0 to 14 years of age and diagnosed with T1D 2006 to 2011 was collected from four Nordic national pediatric quality diabetes registries. Data included year of diagnosis (2006-2011), sex, and age at diagnosis. Figures for number of children at risk during 2006 to 2011—as well as total population, proportion with foreign background and size of populated areas of geographic regions—were collected from official statistics. Results: The total incidence during the study period for all four countries was 35.7/100 000 person years but differed between the countries (range 18.2-44.1; P <.001). The incidence difference between the countries was most obvious in the highest age group, 10 to 14 years of age, whereas there was no difference in the youngest age group 0 to 5 years of age. Iceland had similar incidence in the entire country, whereas the other countries had areas with different incidence. Densely populated areas, such as major cities, had the lowest incidence. Conclusion: The incidence of T1D differed between the Nordic countries and also between the neighboring countries and generally decreased with population density. This indicates that environmental factors may contribute to the level of incidence of T1D.

OriginalsprogEngelsk
TidsskriftPediatric Diabetes
Vol/bind21
Udgave nummer2
Sider (fra-til)259-265
Antal sider7
ISSN1399-543X
DOI
StatusUdgivet - 2020

Bibliografisk note

Funding Information:
The incidence of T1D differed between the Nordic countries and also between the neighboring countries and generally decreased with population density. This indicates that environmental factors may contribute to the level of incidence of T1D. Peer Review The peer review history for this article is available at https://publons.com/publon/10.1111/pedi.12943 . Funding information Swedish Association of Local Authorities and Regions; Swedish Board of Health and Welfare; Health Research Fund of Central Denmark Region; Steering Committee of Swedish Paediatric Diabetes Quality Registry; Norwegian Study group in Childhood and Adolescent Diabetes; The Danish Society for Diabetes in Childhood and Adolescence; Icelandic Thorvaldsens Foundation

Funding Information:
We thank the Icelandic Thorvaldsens Foundation, The Danish Society for Diabetes in Childhood and Adolescence (DanDiabKids), the Norwegian Study group in Childhood and Adolescent Diabetes, and the Steering Committee of Swedish Paediatric Diabetes Quality Registry, SwedDiabKids. Our big thank to Professor Owe Löfman who started the project with us and did a great work at the beginning but unfortunately passed away. This project was supported by the Health Research Fund of Central Denmark Region, and the Swedish Board of Health and Welfare and the Swedish Association of Local Authorities and Regions. The Norwegian Childhood Diabetes Registry is financed by the South‐Eastern Norway Regional Health Authority. The Danish registry is funded by the Danish Regions' Clinical Quality Development Programme. The funding source has no role in data collection or analysis.

Publisher Copyright:
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd

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