Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT. / Jacobsen, Niels; Frisch, Tina; Keiding, Niels; Heilmann, Carsten; Sengeløv, Henrik; Madsen, Hans O.; Dickmeiss, Ebbe; Ryder, Lars P.
I: eJHaem, Bind 3, Nr. 3, 2022, s. 975-979.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Higher recipient pre-transplant FOXP3 mRNA expression is associated with acute leukaemia relapse after HSCT
AU - Jacobsen, Niels
AU - Frisch, Tina
AU - Keiding, Niels
AU - Heilmann, Carsten
AU - Sengeløv, Henrik
AU - Madsen, Hans O.
AU - Dickmeiss, Ebbe
AU - Ryder, Lars P.
N1 - © 2022 The Authors. eJHaem published by British Society for Haematology and John Wiley & Sons Ltd.
PY - 2022
Y1 - 2022
N2 - The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).
AB - The effect of higher FOXP3 mRNA expression by recipient pre-transplant CD4+ T cells on leukaemia relapse was analysed in a series of 106 patients who received allogeneic haematopoietic stem cell transplantation after myeloablative conditioning with or without antithymocyte globulin (ATG) due to acute leukaemia in 1st or 2nd complete remission. FOXP3 mRNA was measured by qPCR in purified CD4+ T cells from blood obtained before conditioning. Higher FOXP3 mRNA expression was associated with an increased relapse risk when conditioning included ATG (n = 43, hazard ratio [HR] 11.0 [2.50-48.4], p = 0.00001). No effect was observed in patients not receiving ATG (HR 0.95 [0.53-1.81]).
U2 - 10.1002/jha2.438
DO - 10.1002/jha2.438
M3 - Journal article
C2 - 36051013
VL - 3
SP - 975
EP - 979
JO - eJHaem
JF - eJHaem
SN - 2688-6146
IS - 3
ER -
ID: 345681169