IDO1 Protein Is Expressed in Diagnostic Biopsies from Both Follicular and Transformed Follicular Patients
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Follicular lymphoma (FL) is a lymphoid neoplasia characterized by an indolent clinical nature. Despite generally favorable prognoses, early progression and histological transformation (HT) to a more aggressive lymphoma histology remain the leading causes of death among FL patients. To provide a basis for possible novel treatment options, we set out to evaluate the expression levels of indoleamine 2,3-dioxygenase 1 (IDO1), an immunoinhibitory checkpoint molecule, in follicular and transformed follicular biopsies. The expression levels of IDO1 were assessed using immunohistochemical staining and digital image analysis in lymphoma biopsies from 33 FL patients without subsequent HT (non-transforming FL, nt-FL) and 20 patients with subsequent HT (subsequently transforming FL, st-FL) as well as in paired high-grade biopsies from the time of HT (transformed FL, tFL). Despite no statistical difference in IDO1 expression levels seen between the groups, all diagnostic and transformed lymphomas exhibited positive expression, indicating its possible role in novel treatment regimens. In addition, IDO1 expression revealed a positive correlation with another immune checkpoint inhibitor, namely programmed death 1 (PD-1). In summary, we report IDO1 expression in all cases of FL and tFL, which provides the grounds for future investigations of anti-IDO1 therapy as a possible treatment for FL patients.
Originalsprog | Engelsk |
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Artikelnummer | 7314 |
Tidsskrift | International Journal of Molecular Sciences |
Vol/bind | 24 |
Udgave nummer | 8 |
Antal sider | 7 |
ISSN | 1661-6596 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The research was funded by grants from Department of Clinical Medicine, Aarhus University, the Karen Elise Jensen Foundation, Merchant Einar Willumsen’s Memorial Foundation, the Danish Lymphoma Group, a donation from Peter and Alice Madsen, Knud and Edith Eriksen’s Memorial Foundation, Eva and Henry Frænkel’s Memorial Foundation, Raimond and Dagmar Ringgård-Bohn’s Foundation, Butcher Max Wørzner and wife Wørzner’s Memorial Grant, Master Carpenter Jørgen Holm and wife Elisa f. Hansen’s Memorial Grant, A.P. Møller Foundation for the Advancement of Medical Sciences, Dagmar Marshall’s Foundation, and Farmer of “Ølufgård” Peder Nielsen Kristensens Memorial Foundation.
Publisher Copyright:
© 2023 by the authors.
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