Kinase Signaling in Colitis-Associated Colon Cancer and Inflammatory Bowel Disease
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Colorectal cancer is a known complication of chronic inflammation of the colon (“colitis-associated colon cancer”). Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Patients with IBD are at increased risk of colon cancer compared to the general population. Kinase signaling pathways play critical roles in both the inflammation and regulating cellular processes such as proliferation and survival that contribute to cancer development. Here we review the interplay of kinase signaling pathways (mitogen-activated protein kinases, cyclin-dependent kinases, autophagy-activated kinases, JAK-STAT, and other kinases) and their effects on colitis-associated colon cancer. We also discuss the role of JAK-STAT signaling in the pathogenesis of IBD and the therapeutic landscape of JAK inhibitors for the treatment of IBD.
Originalsprog | Engelsk |
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Artikelnummer | 1620 |
Tidsskrift | Biomolecules |
Vol/bind | 13 |
Udgave nummer | 11 |
Antal sider | 14 |
ISSN | 2218-273X |
DOI | |
Status | Udgivet - nov. 2023 |
Bibliografisk note
Funding Information:
J.G. is in part supported by a Chan Zuckerberg Biohub Physician Scientist Scholar Award, NIH NIDDK LRP Award (2L30 DK126220), a Doris Duke Physician Scientist Fellowship Award (Grant #2021091), and a Stanford MCHRI Pediatric IBD and Celiac Disease Research Award.
Publisher Copyright:
© 2023 by the authors.
ID: 375406467