Knoglemarvstransplantation og chimeric antigen receptor-T-celleterapi
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Malignant hematologic diseases resistant to chemotherapy can be cured by immune cellular therapy. Bone marrow transplantation (BMT) elicits a "pan-immunologic" attack, whereas therapy with chimeric antigen receptor (CAR)-T is a targeted attack. The immunologic activity after BMT can be adjusted by selection of donor cells before transplantation, or with post-BMT sequential chemotherapy. Many haematologic diseases are clonal, and the development of CAR-T cellular therapy directed against a variety of epitopes is under development as summarised in this review.
Bidragets oversatte titel | Bone marrow transplantation and chimeric antigen receptot T cellular therapy |
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Originalsprog | Dansk |
Artikelnummer | V03210280 |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 183 |
Udgave nummer | 42 |
Antal sider | 8 |
ISSN | 0041-5782 |
Status | Udgivet - 18 okt. 2021 |
- Bone Marrow Transplantation, Humans, Tissue Donors
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Links
- https://content.ugeskriftet.dk/sites/default/files/scientific_article_files/2021-10/v03210280_web.pdf
Forlagets udgivne version
ID: 305690506