Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study. / Petersen, I. S.; Zeuthen, A. B.; Christensen, J. M.; Bartels, M. D.; Johansen, H. H.N.; Johansen, S. P.; Jarløv, J. O.; Mogensen, D.; Pedersen, J.

I: Journal of Hospital Infection, Bind 119, 01.2022, s. 16-21.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Petersen, IS, Zeuthen, AB, Christensen, JM, Bartels, MD, Johansen, HHN, Johansen, SP, Jarløv, JO, Mogensen, D & Pedersen, J 2022, 'Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study', Journal of Hospital Infection, bind 119, s. 16-21. https://doi.org/10.1016/j.jhin.2021.09.025

APA

Petersen, I. S., Zeuthen, A. B., Christensen, J. M., Bartels, M. D., Johansen, H. H. N., Johansen, S. P., Jarløv, J. O., Mogensen, D., & Pedersen, J. (2022). Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study. Journal of Hospital Infection, 119, 16-21. https://doi.org/10.1016/j.jhin.2021.09.025

Vancouver

Petersen IS, Zeuthen AB, Christensen JM, Bartels MD, Johansen HHN, Johansen SP o.a. Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study. Journal of Hospital Infection. 2022 jan.;119:16-21. https://doi.org/10.1016/j.jhin.2021.09.025

Author

Petersen, I. S. ; Zeuthen, A. B. ; Christensen, J. M. ; Bartels, M. D. ; Johansen, H. H.N. ; Johansen, S. P. ; Jarløv, J. O. ; Mogensen, D. ; Pedersen, J. / Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study. I: Journal of Hospital Infection. 2022 ; Bind 119. s. 16-21.

Bibtex

@article{edb404dcddc8402fa02111e4fd8793b3,
title = "Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study",
abstract = "Background: To prevent transmission of, and infection with, meticillin-resistant Staphylococcus aureus (MRSA), eradication treatment of colonized individuals is recommended. Throat colonization is a well-known risk factor for eradication failure. Staphylococcus aureus throat colonization is associated with colonization of the rhinopharynx, but in the currently recommended Danish MRSA eradication strategies, rhinopharynx colonization is not directly targeted. Rhinopharynx colonization could therefore be an important risk factor for prolonged MRSA throat carriage. Aim: To determine whether irrigation and wash of the rhinopharynx and mouth with dissolved mupirocin is a feasible and potentially efficacious supplementary strategy against treatment-resistant MRSA throat carriage. Methods: The patient study was an open, non-blinded, trial including 20 treatment-resistant MRSA throat carriers. In the study, the patients received a supplementary treatment besides the standard treatment according to the Danish MRSA eradication strategy. The supplementary treatment consisted of rhinopharyngeal irrigation and mouth-gurgling twice a day for 14 days with a mupirocin ointment (22 g 2% ointment per litre of isotonic sterile saline solution) in a 37°C solution. Findings: Eighteen patients (90%) complied with the treatment protocol and none ex-perienced any major adverse events. Out of the 18 patients who finished the study per protocol, 15 (83%) and seven (39%) patients had negative MRSA sampling results one and six months after end of treatment, respectively. Conclusion: This study demonstrates the feasibility and clinical potential of also targeting the rhinopharynx and oropharynx in non-systemic throat MRSA eradication strategies.",
keywords = "Carriage, Colonization, Eradication, Irrigation, MRSA, Throat",
author = "Petersen, {I. S.} and Zeuthen, {A. B.} and Christensen, {J. M.} and Bartels, {M. D.} and Johansen, {H. H.N.} and Johansen, {S. P.} and Jarl{\o}v, {J. O.} and D. Mogensen and J. Pedersen",
note = "Publisher Copyright: {\textcopyright} 2021 The Healthcare Infection Society",
year = "2022",
month = jan,
doi = "10.1016/j.jhin.2021.09.025",
language = "English",
volume = "119",
pages = "16--21",
journal = "Journal of Hospital Infection",
issn = "0195-6701",
publisher = "W.B.Saunders Co. Ltd.",

}

RIS

TY - JOUR

T1 - Rhinopharynx irrigations and mouthwash with dissolved mupirocin in treatment of MRSA throat colonization – proof-of-concept study

AU - Petersen, I. S.

AU - Zeuthen, A. B.

AU - Christensen, J. M.

AU - Bartels, M. D.

AU - Johansen, H. H.N.

AU - Johansen, S. P.

AU - Jarløv, J. O.

AU - Mogensen, D.

AU - Pedersen, J.

N1 - Publisher Copyright: © 2021 The Healthcare Infection Society

PY - 2022/1

Y1 - 2022/1

N2 - Background: To prevent transmission of, and infection with, meticillin-resistant Staphylococcus aureus (MRSA), eradication treatment of colonized individuals is recommended. Throat colonization is a well-known risk factor for eradication failure. Staphylococcus aureus throat colonization is associated with colonization of the rhinopharynx, but in the currently recommended Danish MRSA eradication strategies, rhinopharynx colonization is not directly targeted. Rhinopharynx colonization could therefore be an important risk factor for prolonged MRSA throat carriage. Aim: To determine whether irrigation and wash of the rhinopharynx and mouth with dissolved mupirocin is a feasible and potentially efficacious supplementary strategy against treatment-resistant MRSA throat carriage. Methods: The patient study was an open, non-blinded, trial including 20 treatment-resistant MRSA throat carriers. In the study, the patients received a supplementary treatment besides the standard treatment according to the Danish MRSA eradication strategy. The supplementary treatment consisted of rhinopharyngeal irrigation and mouth-gurgling twice a day for 14 days with a mupirocin ointment (22 g 2% ointment per litre of isotonic sterile saline solution) in a 37°C solution. Findings: Eighteen patients (90%) complied with the treatment protocol and none ex-perienced any major adverse events. Out of the 18 patients who finished the study per protocol, 15 (83%) and seven (39%) patients had negative MRSA sampling results one and six months after end of treatment, respectively. Conclusion: This study demonstrates the feasibility and clinical potential of also targeting the rhinopharynx and oropharynx in non-systemic throat MRSA eradication strategies.

AB - Background: To prevent transmission of, and infection with, meticillin-resistant Staphylococcus aureus (MRSA), eradication treatment of colonized individuals is recommended. Throat colonization is a well-known risk factor for eradication failure. Staphylococcus aureus throat colonization is associated with colonization of the rhinopharynx, but in the currently recommended Danish MRSA eradication strategies, rhinopharynx colonization is not directly targeted. Rhinopharynx colonization could therefore be an important risk factor for prolonged MRSA throat carriage. Aim: To determine whether irrigation and wash of the rhinopharynx and mouth with dissolved mupirocin is a feasible and potentially efficacious supplementary strategy against treatment-resistant MRSA throat carriage. Methods: The patient study was an open, non-blinded, trial including 20 treatment-resistant MRSA throat carriers. In the study, the patients received a supplementary treatment besides the standard treatment according to the Danish MRSA eradication strategy. The supplementary treatment consisted of rhinopharyngeal irrigation and mouth-gurgling twice a day for 14 days with a mupirocin ointment (22 g 2% ointment per litre of isotonic sterile saline solution) in a 37°C solution. Findings: Eighteen patients (90%) complied with the treatment protocol and none ex-perienced any major adverse events. Out of the 18 patients who finished the study per protocol, 15 (83%) and seven (39%) patients had negative MRSA sampling results one and six months after end of treatment, respectively. Conclusion: This study demonstrates the feasibility and clinical potential of also targeting the rhinopharynx and oropharynx in non-systemic throat MRSA eradication strategies.

KW - Carriage

KW - Colonization

KW - Eradication

KW - Irrigation

KW - MRSA

KW - Throat

U2 - 10.1016/j.jhin.2021.09.025

DO - 10.1016/j.jhin.2021.09.025

M3 - Journal article

C2 - 34699965

AN - SCOPUS:85120612135

VL - 119

SP - 16

EP - 21

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

ER -

ID: 297013377