The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons
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The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons. / Ullum, Henrik; Palmø, Jan; Halkjær-Kristensen, Jens; Diamant, Marcus; Klokker, Mads; Kruuse, Alexandra; LaPerriere, Arthur; Pedersen, Bente Klarlund.
I: Journal of Acquired Immune Deficiency Syndromes, Bind 7, Nr. 11, 01.01.1994, s. 1122-1133.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons
AU - Ullum, Henrik
AU - Palmø, Jan
AU - Halkjær-Kristensen, Jens
AU - Diamant, Marcus
AU - Klokker, Mads
AU - Kruuse, Alexandra
AU - LaPerriere, Arthur
AU - Pedersen, Bente Klarlund
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.
AB - Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.
KW - Blood mono
KW - Cytokines
KW - HIV seropositive
KW - Interleukins
KW - Lymphocytes
KW - Lymphokine activated killer cells
KW - Natural killer cells
KW - nuclear cell subsets
KW - Physical exercise
KW - Proliferative responses
UR - http://www.scopus.com/inward/record.url?scp=0028170793&partnerID=8YFLogxK
M3 - Journal article
C2 - 7932079
AN - SCOPUS:0028170793
VL - 7
SP - 1122
EP - 1133
JO - J A I D S
JF - J A I D S
SN - 1525-4135
IS - 11
ER -
ID: 203592616