The Effect of acute exercise on lymphocyte subsets, natural killer cells, proliferative responses, and cytokines in hiv-seropositive persons
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Eight healthy men infected with human immunodeficiency virus, type 1 (HIV) and eight HIV seronegative age- and sex-matched controls exercised on a bicycle ergometer (75% of VO2max, 1 h). The percentages of CD4 +, CD4 + 45RA + , and CD4+45RO+ cells did not change, whereas the absolute number of CD4+ cells increased twofold during exercise and fell below prevalues 2 h after. The neutrophil count increase was more pronounced after exercise in the controls compared with in HIV-seropositive subjects. The percent CD16+ cells, and the natural killer (NK) and lymphokine activated killer (LAK) cell activity increased during exercise, but this increase was significantly less pronounced in the HIV-seropositive group. The results suggest that in response to physical stress, HIV-seropositive subjects have an impaired ability to mobilize neutrophils, NK and LAK cells to the blood. Furthermore, because the total number of CD4+ cells, but not the percentage of CD4+ cells, changed in response to exercise, this study further strengthens the idea that the percentage of CD4 + cells is preferable to the number of CD4 + cells in monitoring patients seropositive for HIV.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Acquired Immune Deficiency Syndromes |
Vol/bind | 7 |
Udgave nummer | 11 |
Sider (fra-til) | 1122-1133 |
Antal sider | 12 |
ISSN | 1525-4135 |
Status | Udgivet - 1 jan. 1994 |
ID: 203592616