The time course of development and impact from viral resistance against ganciclovir in cytomegalovirus infection
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
(Val)ganciclovir is used to treat cytomegalovirus (CMV) infection following solid organ (SOT) or hematopoietic stem cell (HSCT) transplantation. Treatment failures occur, but the contribution from 39 known ganciclovir-related mutations (GRMs) in the CMV-UL97 gene remains controversial. We propose a categorization of these GRMs potentially useful when interpreting sequence analyses in clinical settings. The UL97 gene was sequenced from first/recurrent CMV infections among consecutive SOT or HSCT recipients during 2004-2009. GRMs were categorized as: Signature GRM (sGRM) if in vitro ganciclovir IC(50) ratio for mutated versus wild-type virus >2 (n = 24); polymorphic GRM (pGRM) if ratio
Originalsprog | Engelsk |
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Tidsskrift | American Journal of Transplantation (Online) |
Vol/bind | 13 |
Udgave nummer | 2 |
Sider (fra-til) | 458-66 |
Antal sider | 9 |
ISSN | 1600-6143 |
DOI | |
Status | Udgivet - feb. 2013 |
ID: 105597872