Impact of serial cardiopulmonary point-of-care ultrasound exams in patients with acute dyspnoea: A randomised, controlled trial
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Impact of serial cardiopulmonary point-of-care ultrasound exams in patients with acute dyspnoea : A randomised, controlled trial. / Arvig, Michael Dan; Lassen, Annmarie Touborg; Gæde, Peter Haulund; Gärtner, Stefan Wernblad; Falster, Casper; Skov, Inge Raadal; Petersen, Henrik Ømark; Posth, Stefan; Laursen, Christian B.
I: Emergency Medicine Journal, Bind 40, Nr. 10, 2023, s. 700-707.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impact of serial cardiopulmonary point-of-care ultrasound exams in patients with acute dyspnoea
T2 - A randomised, controlled trial
AU - Arvig, Michael Dan
AU - Lassen, Annmarie Touborg
AU - Gæde, Peter Haulund
AU - Gärtner, Stefan Wernblad
AU - Falster, Casper
AU - Skov, Inge Raadal
AU - Petersen, Henrik Ømark
AU - Posth, Stefan
AU - Laursen, Christian B.
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2023
Y1 - 2023
N2 - Background Serial point-of-care ultrasound (PoCUS) can potentially improve acute patient care through treatment adjusted to the dynamic ultrasound findings. The objective was to investigate if treatment guided by monitoring patients with acute dyspnoea with serial cardiopulmonary PoCUS and usual care could reduce the severity of dyspnoea compared with usual care alone. Methods This was a randomised, controlled, blinded-outcome trial conducted in three EDs in Denmark between 9 October 2019 and 26 May 2021. Patients aged ≥18 years admitted with a primary complaint of dyspnoea were allocated 1:1 with block randomisation to usual care, which included a single cardiopulmonary PoCUS within 1 hour of arrival (control group) or usual care (including a PoCUS within 1 hour of arrival) plus two additional PoCUS performed at 2 hours interval from the initial PoCUS (serial ultrasound group). The primary outcome was a reduction of dyspnoea measured on a verbal dyspnoea scale (VDS) from 0 to 10 recorded at inclusion and after 2, 4 and 5 hours. Results There were 206 patients recruited, 102 in the serial ultrasound group and 104 in the control group, all of whom had complete follow-up. The mean difference in VDS between patients in the serial ultrasound and the control group was -1.09 (95% CI -1.51 to -0.66) and -1.66 (95% CI -2.09 to -1.23) after 4 and 5 hours, respectively. The effect was more pronounced in patients with a presumptive diagnosis of acute heart failure (AHF). A larger proportion of patients received diuretics in the serial ultrasound group. Conclusion Therapy guided by serial cardiopulmonary PoCUS may, together with usual care, facilitate greater improvement in the severity of dyspnoea, especially in patients with AHF compared with usual care with a single PoCUS in the ED. Serial PoCUS should therefore be considered for routine use to aid the physician in stabilising the patient faster. Trial registration number NCT04091334.
AB - Background Serial point-of-care ultrasound (PoCUS) can potentially improve acute patient care through treatment adjusted to the dynamic ultrasound findings. The objective was to investigate if treatment guided by monitoring patients with acute dyspnoea with serial cardiopulmonary PoCUS and usual care could reduce the severity of dyspnoea compared with usual care alone. Methods This was a randomised, controlled, blinded-outcome trial conducted in three EDs in Denmark between 9 October 2019 and 26 May 2021. Patients aged ≥18 years admitted with a primary complaint of dyspnoea were allocated 1:1 with block randomisation to usual care, which included a single cardiopulmonary PoCUS within 1 hour of arrival (control group) or usual care (including a PoCUS within 1 hour of arrival) plus two additional PoCUS performed at 2 hours interval from the initial PoCUS (serial ultrasound group). The primary outcome was a reduction of dyspnoea measured on a verbal dyspnoea scale (VDS) from 0 to 10 recorded at inclusion and after 2, 4 and 5 hours. Results There were 206 patients recruited, 102 in the serial ultrasound group and 104 in the control group, all of whom had complete follow-up. The mean difference in VDS between patients in the serial ultrasound and the control group was -1.09 (95% CI -1.51 to -0.66) and -1.66 (95% CI -2.09 to -1.23) after 4 and 5 hours, respectively. The effect was more pronounced in patients with a presumptive diagnosis of acute heart failure (AHF). A larger proportion of patients received diuretics in the serial ultrasound group. Conclusion Therapy guided by serial cardiopulmonary PoCUS may, together with usual care, facilitate greater improvement in the severity of dyspnoea, especially in patients with AHF compared with usual care with a single PoCUS in the ED. Serial PoCUS should therefore be considered for routine use to aid the physician in stabilising the patient faster. Trial registration number NCT04091334.
KW - acute care
KW - acute medicine
KW - crowding
KW - respiratory
KW - ultrasonography
U2 - 10.1136/emermed-2022-212694
DO - 10.1136/emermed-2022-212694
M3 - Journal article
C2 - 37595984
AN - SCOPUS:85170224454
VL - 40
SP - 700
EP - 707
JO - Emergency Medicine Journal
JF - Emergency Medicine Journal
SN - 1472-0205
IS - 10
ER -
ID: 370567397