Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years
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Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years. / Fagerlund, Birgitte; Pantelis, Christos; Jepsen, Jens Richardt Møllegaard; Raghava, Jayachandra Mitta; Rostrup, Egill; Thomas, Marie Bjerregaard; Nielsen, Mette Ødegaard; Bojesen, Kirsten; Jensen, Karsten Gjessing; Stentebjerg-Decara, Marie; Klauber, Dea Gowers; Rudå, Ditte; Ebdrup, Bjørn H.; Jessen, Kasper; Sigvard, Anne; Tangmose, Karen; Jeppesen, Pia; Correll, Christoph U.; Fink-Jensen, Anders; Pagsberg, Anne Katrine; Glenthøj, Birte Yding.
I: Psychological Medicine, Bind 51, Nr. 9, 2021, s. 1570-1580.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Differential effects of age at illness onset on verbal memory functions in antipsychotic-naïve schizophrenia patients aged 12-43 years
AU - Fagerlund, Birgitte
AU - Pantelis, Christos
AU - Jepsen, Jens Richardt Møllegaard
AU - Raghava, Jayachandra Mitta
AU - Rostrup, Egill
AU - Thomas, Marie Bjerregaard
AU - Nielsen, Mette Ødegaard
AU - Bojesen, Kirsten
AU - Jensen, Karsten Gjessing
AU - Stentebjerg-Decara, Marie
AU - Klauber, Dea Gowers
AU - Rudå, Ditte
AU - Ebdrup, Bjørn H.
AU - Jessen, Kasper
AU - Sigvard, Anne
AU - Tangmose, Karen
AU - Jeppesen, Pia
AU - Correll, Christoph U.
AU - Fink-Jensen, Anders
AU - Pagsberg, Anne Katrine
AU - Glenthøj, Birte Yding
PY - 2021
Y1 - 2021
N2 - BackgroundThe typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition.MethodsThe aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- A nd sex-matched HCs. Diagnoses were made according to ICD-10 criteria. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS), and IQ was estimated using subtests from the Wechsler adult-or child-intelligence scales. Multivariate analysis of covariance (MANCOVA) was used to examine linear and quadratic effects of age on cognitive scores and interactions by group, including sex and parental socioeconomic status as covariates.ResultsThere was a significant overall effect of age on BACS and IQ (p < 0.001). Significant group-by-age interactions for verbal memory (for age-squared, p = 0.009), and digit sequencing (for age, p = 0.01; age-squared, p < 0.001), indicated differential age-related trajectories between patients and HCs.ConclusionsCognitive functions showing protracted maturation into adulthood, such as verbal memory and verbal working memory, may be particularly impaired in both early- A nd late-schizophrenia onset. Our findings indicate a potential interaction between the timing of neurodevelopmental maturation and a possible premature age effect in late-onset schizophrenia.
AB - BackgroundThe typical onset of schizophrenia coincides with the maturational peak in cognition; however, for a significant proportion of patients the onset is before age 18 and after age 30 years. While cognitive deficits are considered core features of schizophrenia, few studies have directly examined the impact of age of illness onset on cognition.MethodsThe aim of the study was to examine if the effects of age on cognition differ between healthy controls (HCs) and patients with schizophrenia at illness onset. We examined 156 first-episode antipsychotic-naïve patients across a wide age span (12-43 years), and 161 age- A nd sex-matched HCs. Diagnoses were made according to ICD-10 criteria. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS), and IQ was estimated using subtests from the Wechsler adult-or child-intelligence scales. Multivariate analysis of covariance (MANCOVA) was used to examine linear and quadratic effects of age on cognitive scores and interactions by group, including sex and parental socioeconomic status as covariates.ResultsThere was a significant overall effect of age on BACS and IQ (p < 0.001). Significant group-by-age interactions for verbal memory (for age-squared, p = 0.009), and digit sequencing (for age, p = 0.01; age-squared, p < 0.001), indicated differential age-related trajectories between patients and HCs.ConclusionsCognitive functions showing protracted maturation into adulthood, such as verbal memory and verbal working memory, may be particularly impaired in both early- A nd late-schizophrenia onset. Our findings indicate a potential interaction between the timing of neurodevelopmental maturation and a possible premature age effect in late-onset schizophrenia.
KW - Age of illness onset
KW - cognition
KW - neurodevelopmental
KW - schizophrenia
U2 - 10.1017/S0033291720000409
DO - 10.1017/S0033291720000409
M3 - Journal article
C2 - 32156323
AN - SCOPUS:85082006640
VL - 51
SP - 1570
EP - 1580
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 9
ER -
ID: 250387646