Association of atopic dermatitis with smoking: A systematic review and meta-analysis
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
BACKGROUND: Tobacco exposure might be a modifiable risk factor for atopic dermatitis (AD).
OBJECTIVE: We examine the association between AD and exposure to tobacco smoke.
METHODS: We performed a systematic review and meta-analysis of observational studies (n = 86) in MEDLINE, EMBASE, Scopus, and Cochrane Library (1823-2015). Quality of evidence was assessed using the Newcastle-Ottawa Scale (NOS). A meta-analysis was performed using random-effects models to estimate pooled odds ratios (OR). Subset analyses were performed for different ages (children, adult), regions, study designs (cross-sectional, longitudinal), study sizes (<5000, ≥5000), study quality (NOS score <6, ≥6), and amount of smoking (mild, extensive).
RESULTS: A diagnosis of AD was associated with higher odds of active smoking (OR 1.87, 95% confidence interval 1.32-2.63) and exposure to passive smoke (OR 1.18, 95% confidence interval 1.01-1.38), but not maternal smoking during pregnancy (OR 1.06, 95% confidence interval 0.80-1.40). The association between active smoking and AD remained significant in children and adults, all continents studied, and study sizes, but all were cross-sectional designs and had NOS score 6 or greater. Passive smoke was associated with AD in children and adults, cross-sectional studies, South/Central American and African studies, study size less than 5000, and NOS score less than 6.
LIMITATIONS: AD severity and distribution were not assessed.
CONCLUSIONS: Active and passive exposure to smoke are associated with increased AD prevalence.
Originalsprog | Engelsk |
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Tidsskrift | Journal of the American Academy of Dermatology |
Vol/bind | 75 |
Udgave nummer | 6 |
Sider (fra-til) | 1119-1125.e1 |
Antal sider | 8 |
ISSN | 0190-9622 |
DOI | |
Status | Udgivet - dec. 2016 |
ID: 177054369