Changes in basal rates and bolus calculator settings in insulin pumps during pregnancy in women with type 1 diabetes
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Changes in basal rates and bolus calculator settings in insulin pumps during pregnancy in women with type 1 diabetes. / Mathiesen, Jonathan M; Secher, Anna L; Ringholm, Lene; Nørgaard, Kirsten; Hommel, Eva; Andersen, Henrik U; Damm, Peter; Mathiesen, Elisabeth R.
I: Journal of Maternal - Fetal & Neonatal Medicine, Bind 27, Nr. 7, 2014, s. 724-728.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Changes in basal rates and bolus calculator settings in insulin pumps during pregnancy in women with type 1 diabetes
AU - Mathiesen, Jonathan M
AU - Secher, Anna L
AU - Ringholm, Lene
AU - Nørgaard, Kirsten
AU - Hommel, Eva
AU - Andersen, Henrik U
AU - Damm, Peter
AU - Mathiesen, Elisabeth R
PY - 2014
Y1 - 2014
N2 - OBJECTIVE: To explore insulin pump settings in a cohort of pregnant women with type 1 diabetes on insulin pump therapy with a bolus calculator.METHODS: Twenty-seven women with type 1 diabetes on insulin pump therapy were included in this study. At 8, 12, 21, 27 and 33 weeks, insulin pump settings and HbA1c were recorded. Results were compared with 96 women with type 1 diabetes on multiple daily injection therapy.RESULTS: Throughout pregnancy, the carbohydrate-to-insulin ratio decreased at all three main meals. The most pronounced decrease was observed at breakfast, where the carbohydrate-to-insulin ratio was reduced, from median 12 (range 4-20) in early pregnancy to 3 (2-10) g carbohydrate per unit insulin in late pregnancy. Basal insulin delivery increased by ∼50%, i.e. from 0.8 (0.5-2.2) to 1.2 (0.6-2.5) IU/h at 5 a.m. and from 1.0 (0.6-1.5) to 1.3 (0.2-2.3) IU/h at 5 p.m. during pregnancy. HbA1c levels during pregnancy, the occurrence of severe hypoglycemia and pregnancy outcomes were similar in the two groups.CONCLUSIONS: In women with type 1 diabetes on insulin pump therapy with a bolus calculator, the carbohydrate-to-insulin ratio declined 4-fold from early to late pregnancy, whereas changes in basal insulin delivery were smaller.
AB - OBJECTIVE: To explore insulin pump settings in a cohort of pregnant women with type 1 diabetes on insulin pump therapy with a bolus calculator.METHODS: Twenty-seven women with type 1 diabetes on insulin pump therapy were included in this study. At 8, 12, 21, 27 and 33 weeks, insulin pump settings and HbA1c were recorded. Results were compared with 96 women with type 1 diabetes on multiple daily injection therapy.RESULTS: Throughout pregnancy, the carbohydrate-to-insulin ratio decreased at all three main meals. The most pronounced decrease was observed at breakfast, where the carbohydrate-to-insulin ratio was reduced, from median 12 (range 4-20) in early pregnancy to 3 (2-10) g carbohydrate per unit insulin in late pregnancy. Basal insulin delivery increased by ∼50%, i.e. from 0.8 (0.5-2.2) to 1.2 (0.6-2.5) IU/h at 5 a.m. and from 1.0 (0.6-1.5) to 1.3 (0.2-2.3) IU/h at 5 p.m. during pregnancy. HbA1c levels during pregnancy, the occurrence of severe hypoglycemia and pregnancy outcomes were similar in the two groups.CONCLUSIONS: In women with type 1 diabetes on insulin pump therapy with a bolus calculator, the carbohydrate-to-insulin ratio declined 4-fold from early to late pregnancy, whereas changes in basal insulin delivery were smaller.
KW - Algorithms
KW - Cohort Studies
KW - Diabetes Mellitus, Type 1
KW - Female
KW - Humans
KW - Hypoglycemic Agents
KW - Insulin
KW - Insulin Infusion Systems
KW - Pregnancy
KW - Pregnancy in Diabetics
U2 - 10.3109/14767058.2013.837444
DO - 10.3109/14767058.2013.837444
M3 - Journal article
C2 - 23981186
VL - 27
SP - 724
EP - 728
JO - Journal of Maternal-Fetal Medicine
JF - Journal of Maternal-Fetal Medicine
SN - 1476-7058
IS - 7
ER -
ID: 138502748