Changes in the pattern of paracetamol use in the periconception period in a Danish cohort
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Changes in the pattern of paracetamol use in the periconception period in a Danish cohort. / Ersbøll, Anne S; Hedegaard, Mette; Damm, Peter; Johansen, Marianne; Tabor, Ann; Hegaard, Hanne K.
I: Acta Obstetricia et Gynecologica Scandinavica, Bind 94, Nr. 8, 08.2015, s. 898-903.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Changes in the pattern of paracetamol use in the periconception period in a Danish cohort
AU - Ersbøll, Anne S
AU - Hedegaard, Mette
AU - Damm, Peter
AU - Johansen, Marianne
AU - Tabor, Ann
AU - Hegaard, Hanne K
N1 - © 2015 Nordic Federation of Societies of Obstetrics and Gynecology.
PY - 2015/8
Y1 - 2015/8
N2 - Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3 months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index ≥ 25 kg/m(2), unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.
AB - Paracetamol is the most commonly used over-the-counter drug in pregnancy. It is generally considered to be safe, but prolonged antenatal exposure has been associated with offspring short- and long-term morbidity. Our aim was to describe the pattern of paracetamol use with a focus on frequent ingestion (more than once a week), 3 months before and in early pregnancy. In this cohort, 8650 pregnant women responded to a web-based clinical questionnaire that included questions about drug use. Paracetamol was the most used drug before and in early pregnancy (35.2% and 6.5% of respondents, respectively). The proportion of frequent users decreased from 3.9% before to 0.9% in early pregnancy. Frequent paracetamol use was associated with smoking, co-morbidities, body mass index ≥ 25 kg/m(2), unplanned pregnancy, no education and inability to understand Danish. A significant decrease in the proportion of women with any paracetamol use in early pregnancy was noted after access to large packs was restricted by legislation.
KW - Acetaminophen
KW - Adult
KW - Analgesics, Non-Narcotic
KW - Cohort Studies
KW - Female
KW - Health Behavior
KW - Humans
KW - Pregnancy
KW - Pregnancy Trimester, First
KW - Socioeconomic Factors
KW - Surveys and Questionnaires
KW - Sweden
KW - Young Adult
U2 - 10.1111/aogs.12667
DO - 10.1111/aogs.12667
M3 - Journal article
C2 - 25939806
VL - 94
SP - 898
EP - 903
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 8
ER -
ID: 160099587