Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes
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Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature Metabolism |
Vol/bind | 6 |
Sider (fra-til) | 1268–1281 |
ISSN | 2522-5812 |
DOI | |
Status | Udgivet - 2024 |
Bibliografisk note
Funding Information:
This work was supported by a scholarship to H.S.K. from the Danish Diabetes Academy funded by the Novo Nordisk Foundation (grant no. NNF17SA0031406) and a grant to M.M.R. from the EFSD/Lilly European Diabetes Research Programme. M.M.R was also supported by a grant from the Novo Nordisk Foundation (grant no. NNF21OC0070347). K.V.S., J.B.-J., O.P., B.H., J.J.H., T.H. and N.G. were supported by an unrestricted grant (NNF18CC0034900 and NNF23SA0084103) donated by the Novo Nordisk Foundation to partly fund the independent research facility of the Novo Nordisk Foundation Center for Basic Metabolic Research. A.S.H. and J.S.M. gratefully acknowledge funding from the Lundbeck Foundation (R278-2018-180) and the Independent Research Fund Denmark (3122-00044B). A.V. was supported by The Swedish Research Council, Strategic Research Area Exodiab, Dnr 2009-1039, and Swedish Foundation for Strategic Research, Dnr ICR15-0067. S.C.W. is supported by the Swedish Society for Medical Research (PD20-0153). V.M.L. is supported by the Swedish Research Council (grant agreement numbers 2019-01837 and 2021-02801), by the EU/EFPIA/OICR/McGill/KTH/Diamond Innovative Medicines Initiative 2 Joint Undertaking (EUbOPEN grant number 875510) and by the Robert Bosch Foundation, Stuttgart, Germany.
Funding Information:
DD2 is supported by Danish Agency for Science (grant no. 09-067009 and 09-075724). DD2 is also supported by The Danish Health and Medicines Authority, The Danish Diabetes Association and an unrestricted donation from Novo Nordisk Foundation. The partners of the project are listed on the project website at www.DD2.nu . This research has been conducted using the UK Biobank Resource, a major biomedical database with genotype and phenotype data open to all approved health researchers ( https://www.ukbiobank.ac.uk/ ), under application number 55955. We thank A. Inoue (Tohoku University) for providing \u03B2-arrestin knockout cell lines; M. Bouvier (Universit\u00E9 de Montr\u00E9al) for rGFP-CAAX, rGFP-FYVE, tdrGFP-Giantin and tdrGFP-PTP1B; N.A. Lambert (Augusta University) for Rluc8-mGs; and M. Sigvardt Baggesen, S. Petersen, R. Regmi and A. Dragan for excellent technical assistance for the in vitro studies. Graphic illustrations were created with BioRender.com .
Publisher Copyright:
© The Author(s) 2024.
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