Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes: the EPICOM study
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Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes : the EPICOM study. / Vlachová, Zuzana; Bytoft, Birgitte; Knorr, Sine; Clausen, Tine D; Jensen, Rikke Beck; Mathiesen, Elisabeth R; Højlund, Kurt; Ovesen, Per; Beck-Nielsen, Henning; Gravholt, Claus H; Damm, Peter; Jensen, Dorte M.
I: Diabetologia, Bind 58, Nr. 7, 07.2015, s. 1454-63.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased metabolic risk in adolescent offspring of mothers with type 1 diabetes
T2 - the EPICOM study
AU - Vlachová, Zuzana
AU - Bytoft, Birgitte
AU - Knorr, Sine
AU - Clausen, Tine D
AU - Jensen, Rikke Beck
AU - Mathiesen, Elisabeth R
AU - Højlund, Kurt
AU - Ovesen, Per
AU - Beck-Nielsen, Henning
AU - Gravholt, Claus H
AU - Damm, Peter
AU - Jensen, Dorte M
PY - 2015/7
Y1 - 2015/7
N2 - AIMS/HYPOTHESIS: We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers.METHODS: During 1993-1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed.RESULTS: We examined 278 index offspring (mean age 16.7 years; range 13.0-19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5-20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA1c levels in pregnancy were not directly associated with offspring metabolic outcomes.CONCLUSIONS/INTERPRETATION: Adolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA1c levels in pregnancy could not be demonstrated.TRIAL REGISTRATION: ClinicalTrials.gov NCT01559181.
AB - AIMS/HYPOTHESIS: We aimed to investigate metabolic risk factors, insulin sensitivity and insulin secretion in adolescent offspring of mothers with type 1 diabetes compared with offspring of non-diabetic mothers.METHODS: During 1993-1999, pregnancies of women with type 1 diabetes in Denmark were prospectively reported to a central registry in the Danish Diabetes Association. Data included information on maternal demography, diabetes status and pregnancy outcome. We invited 746 eligible children from this cohort (index offspring) to a follow-up examination. Control offspring were identified through The Danish Central Office of Civil Registration and matched with respect to date of birth, sex and postal code. Anthropometric measurements and blood sampling for metabolic characterisation, including an oral glucose tolerance test, were performed.RESULTS: We examined 278 index offspring (mean age 16.7 years; range 13.0-19.8 years) and 303 control offspring (mean age 16.8 years; range 13.5-20.4 years). Index offspring had higher BMI SD score (0.44: 95% CI 0.21, 0.66) compared with controls, after adjustments for pubertal development and maternal pre-pregnancy BMI. Furthermore, index offspring had a higher prevalence of components included in metabolic syndrome and prediabetes (impaired fasting glucose and/or impaired glucose tolerance), with reduced insulin sensitivity and relative insulin secretion deficiency, compared with controls. Maternal HbA1c levels in pregnancy were not directly associated with offspring metabolic outcomes.CONCLUSIONS/INTERPRETATION: Adolescent offspring of mothers with type 1 diabetes had a less favourable metabolic profile and higher frequency of prediabetes than the background population. Significant associations between these outcomes and maternal HbA1c levels in pregnancy could not be demonstrated.TRIAL REGISTRATION: ClinicalTrials.gov NCT01559181.
KW - Adolescent
KW - Adult
KW - Anthropometry
KW - Denmark
KW - Diabetes Mellitus, Type 1
KW - European Continental Ancestry Group
KW - Female
KW - Glucose Tolerance Test
KW - Hemoglobin A, Glycosylated
KW - Humans
KW - Insulin
KW - Insulin Resistance
KW - Male
KW - Metabolic Diseases
KW - Mothers
KW - Pregnancy
KW - Pregnancy Outcome
KW - Pregnancy in Diabetics
KW - Risk Factors
KW - Young Adult
U2 - 10.1007/s00125-015-3589-5
DO - 10.1007/s00125-015-3589-5
M3 - Journal article
C2 - 25924986
VL - 58
SP - 1454
EP - 1463
JO - Diabetologia
JF - Diabetologia
SN - 0012-186X
IS - 7
ER -
ID: 160048699