Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes. / Jensen, Dorte M; Korsholm, Lars; Ovesen, Per; Beck-Nielsen, Henning; Moelsted-Pedersen, Lars; Westergaard, Jes G; Moeller, Margrethe; Damm, Peter; Jensen, Dorte; Lauridsen, Lars Korsholm; Ovesen, Per Glud; Beck-Nielsen, Henning; Moelsted-Pedersen, Lars; Westergaard, Jes G; Moeller, Margrethe; Damm, Peter.
I: Diabetes Care, Bind 32, Nr. 6, 01.06.2009, s. 1046-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Peri-conceptional A1C and risk of serious adverse pregnancy outcome in 933 women with type 1 diabetes
AU - Jensen, Dorte M
AU - Korsholm, Lars
AU - Ovesen, Per
AU - Beck-Nielsen, Henning
AU - Moelsted-Pedersen, Lars
AU - Westergaard, Jes G
AU - Moeller, Margrethe
AU - Damm, Peter
AU - Jensen, Dorte
AU - Lauridsen, Lars Korsholm
AU - Ovesen, Per Glud
AU - Beck-Nielsen, Henning
AU - Moelsted-Pedersen, Lars
AU - Westergaard, Jes G
AU - Moeller, Margrethe
AU - Damm, Peter
N1 - Keywords: Body Mass Index; Chromosome Aberrations; Diabetes Mellitus, Type 1; European Continental Ancestry Group; Female; Hemoglobin A, Glycosylated; Humans; Infant, Newborn; Perinatal Mortality; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Prospective Studies; Retrospective Studies
PY - 2009/6/1
Y1 - 2009/6/1
N2 - OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.
AB - OBJECTIVE: To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS: Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS: The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS: These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.
U2 - 10.2337/dc08-2061
DO - 10.2337/dc08-2061
M3 - Journal article
C2 - 19265024
VL - 32
SP - 1046
EP - 1048
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 6
ER -
ID: 19953858