TY - JOUR

T1 - Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters

T2 - a secondary analysis of the DALI study

AU - Dieberger, Anna M.

AU - Obermayer-Pietsch, Barbara

AU - Harreiter, Jürgen

AU - Desoye, Gernot

AU - van Poppel, Mireille N.M.

AU - Simmons, David

AU - Corcoy, Rosa

AU - Perez, Juan M.Adelantado

AU - Kautzky-Willer, Alexandra

AU - Damm, Peter

AU - Mathiesen, Elizabeth

AU - Jensen, Dorte M.

AU - Andersen, Lise Lotte T.

AU - Dunne, Fidelma

AU - Lapolla, Annunziata

AU - Dalfra, Maria G.

AU - Bertolotto, Alessandra

AU - Jelsma, Judith G.M.

AU - Galjaard, Sander

AU - Wender-Ozegowska, Ewa

AU - Zawiejska, Agnieszka

AU - Hill, David

AU - Devlieger, Roland

AU - Snoek, Frank J.

AU - DALI Core Investigator Group

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Background/Objectives: Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex. Subjects/Methods: Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI ≥ 29 kg/m2 were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered. Results: Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (−0.520%; 95% CI: −1.011%, −0.031% and −4.649%; −7.876%, −1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (−0.145 µg/l; −0.279 µg/l, −0.005 µg/l). No associations were found with birthweight or other cord blood parameters. Conclusions: Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.

AB - Background/Objectives: Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex. Subjects/Methods: Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI ≥ 29 kg/m2 were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered. Results: Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (−0.520%; 95% CI: −1.011%, −0.031% and −4.649%; −7.876%, −1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (−0.145 µg/l; −0.279 µg/l, −0.005 µg/l). No associations were found with birthweight or other cord blood parameters. Conclusions: Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.

UR - http://www.scopus.com/inward/record.url?scp=85165961368&partnerID=8YFLogxK

U2 - 10.1038/s41366-023-01347-9

DO - 10.1038/s41366-023-01347-9

M3 - Journal article

C2 - 37500924

AN - SCOPUS:85165961368

VL - 47

SP - 873

EP - 881

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 9

ER -