Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

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Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. / Lauenborg, J; Damm, P; Ek, J; Glümer, C; Jørgensen, T; Borch-Johnsen, K; Vestergaard, H; Hornnes, P; Pedersen, O; Hansen, Torben.

I: Diabetic Medicine, Bind 21, Nr. 12, 12.2004, s. 1310-5.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Lauenborg, J, Damm, P, Ek, J, Glümer, C, Jørgensen, T, Borch-Johnsen, K, Vestergaard, H, Hornnes, P, Pedersen, O & Hansen, T 2004, 'Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus', Diabetic Medicine, bind 21, nr. 12, s. 1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

APA

Lauenborg, J., Damm, P., Ek, J., Glümer, C., Jørgensen, T., Borch-Johnsen, K., Vestergaard, H., Hornnes, P., Pedersen, O., & Hansen, T. (2004). Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. Diabetic Medicine, 21(12), 1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

Vancouver

Lauenborg J, Damm P, Ek J, Glümer C, Jørgensen T, Borch-Johnsen K o.a. Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. Diabetic Medicine. 2004 dec.;21(12):1310-5. https://doi.org/10.1111/j.1464-5491.2004.01343.x

Author

Lauenborg, J ; Damm, P ; Ek, J ; Glümer, C ; Jørgensen, T ; Borch-Johnsen, K ; Vestergaard, H ; Hornnes, P ; Pedersen, O ; Hansen, Torben. / Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus. I: Diabetic Medicine. 2004 ; Bind 21, Nr. 12. s. 1310-5.

Bibtex

@article{c5be1aa29a574f108d376229dc8124be,
title = "Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus",
abstract = "In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.",
keywords = "Adult, C-Peptide, Case-Control Studies, DNA-Binding Proteins, Diabetes, Gestational, Female, Glucose Tolerance Test, Hepatocyte Nuclear Factor 1, Hepatocyte Nuclear Factor 1-alpha, Humans, Insulin, Islets of Langerhans, Nuclear Proteins, Polymorphism, Genetic, Pregnancy, Statistics, Nonparametric, Transcription Factors",
author = "J Lauenborg and P Damm and J Ek and C Gl{\"u}mer and T J{\o}rgensen and K Borch-Johnsen and H Vestergaard and P Hornnes and O Pedersen and Torben Hansen",
year = "2004",
month = dec,
doi = "10.1111/j.1464-5491.2004.01343.x",
language = "English",
volume = "21",
pages = "1310--5",
journal = "Diabetic Medicine",
issn = "0742-3071",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - Studies of the Ala/Val98 polymorphism of the hepatocyte nuclear factor-1alpha gene and the relationship to beta-cell function during an OGTT in glucose-tolerant women with and without previous gestational diabetes mellitus

AU - Lauenborg, J

AU - Damm, P

AU - Ek, J

AU - Glümer, C

AU - Jørgensen, T

AU - Borch-Johnsen, K

AU - Vestergaard, H

AU - Hornnes, P

AU - Pedersen, O

AU - Hansen, Torben

PY - 2004/12

Y1 - 2004/12

N2 - In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.

AB - In pregnancies complicated by gestational diabetes mellitus (GDM) an increased demand for insulin is not met due to beta-cell dysfunction. An Ala/Val polymorphism at codon 98 of the hepatocyte nuclear factor-1alpha (HNF-1alpha) gene has been associated with decreased serum insulin and C-peptide responses during an oral glucose tolerance test (OGTT) in glucose-tolerant subjects. The aims of the present study were to evaluate the influence of the polymorphism on the serum insulin and C-peptide responses to an OGTT in glucose-tolerant women with and without previous GDM and to investigate if this polymorphism is associated with GDM.

KW - Adult

KW - C-Peptide

KW - Case-Control Studies

KW - DNA-Binding Proteins

KW - Diabetes, Gestational

KW - Female

KW - Glucose Tolerance Test

KW - Hepatocyte Nuclear Factor 1

KW - Hepatocyte Nuclear Factor 1-alpha

KW - Humans

KW - Insulin

KW - Islets of Langerhans

KW - Nuclear Proteins

KW - Polymorphism, Genetic

KW - Pregnancy

KW - Statistics, Nonparametric

KW - Transcription Factors

U2 - 10.1111/j.1464-5491.2004.01343.x

DO - 10.1111/j.1464-5491.2004.01343.x

M3 - Journal article

C2 - 15569134

VL - 21

SP - 1310

EP - 1315

JO - Diabetic Medicine

JF - Diabetic Medicine

SN - 0742-3071

IS - 12

ER -

ID: 92192045