A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes

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Standard

A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes. / Hod, Moshe; Mathiesen, Elisabeth R; Jovanovič, Lois; McCance, David R; Ivanisevic, Marina; Durán-Garcia, Santiago; Brøndsted, Lise; Nazeri, Avideh; Damm, Peter.

I: Journal of Maternal - Fetal & Neonatal Medicine, Bind 27, Nr. 1, 01.2014, s. 7-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hod, M, Mathiesen, ER, Jovanovič, L, McCance, DR, Ivanisevic, M, Durán-Garcia, S, Brøndsted, L, Nazeri, A & Damm, P 2014, 'A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes', Journal of Maternal - Fetal & Neonatal Medicine, bind 27, nr. 1, s. 7-13. https://doi.org/10.3109/14767058.2013.799650

APA

Hod, M., Mathiesen, E. R., Jovanovič, L., McCance, D. R., Ivanisevic, M., Durán-Garcia, S., Brøndsted, L., Nazeri, A., & Damm, P. (2014). A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes. Journal of Maternal - Fetal & Neonatal Medicine, 27(1), 7-13. https://doi.org/10.3109/14767058.2013.799650

Vancouver

Hod M, Mathiesen ER, Jovanovič L, McCance DR, Ivanisevic M, Durán-Garcia S o.a. A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes. Journal of Maternal - Fetal & Neonatal Medicine. 2014 jan.;27(1):7-13. https://doi.org/10.3109/14767058.2013.799650

Author

Hod, Moshe ; Mathiesen, Elisabeth R ; Jovanovič, Lois ; McCance, David R ; Ivanisevic, Marina ; Durán-Garcia, Santiago ; Brøndsted, Lise ; Nazeri, Avideh ; Damm, Peter. / A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes. I: Journal of Maternal - Fetal & Neonatal Medicine. 2014 ; Bind 27, Nr. 1. s. 7-13.

Bibtex

@article{bcd587dcebec45af8a31a5e15bcc5f2f,
title = "A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes",
abstract = "OBJECTIVE: This randomized controlled trial aimed to compare the efficacy and safety of insulin detemir (IDet) with neutral protamine Hagedorn (NPH), both with insulin aspart, in pregnant women with type 1 diabetes. The perinatal and obstetric pregnancy outcomes are presented.METHODS: Subjects were randomized to IDet (n = 152) or NPH (n = 158) ≤12 months before pregnancy or at 8-12 gestational weeks.RESULTS: For IDet and NPH, there were 128 and 136 live births, 11 and 9 early fetal losses, and two and one perinatal deaths, respectively. Gestational age at delivery was greater for children from the IDet arm than the NPH arm (treatment difference: 0.49 weeks [95% CI 0.11;0.88], p = 0.012, linear regression). Sixteen children had a malformation (IDet: n = 8/142, 5.6%; NPH: n = 8/145, 5.5%). The incidence of adverse events was similar between treatments.CONCLUSION: IDet is as well tolerated as NPH as regards perinatal outcomes in pregnant women with type 1 diabetes and no safety issues were identified.",
keywords = "Abortion, Induced, Abortion, Spontaneous, Congenital Abnormalities, Diabetes Mellitus, Type 1, Drug Combinations, Female, Fetal Death, Gestational Age, Humans, Hypoglycemic Agents, Insulin Aspart, Insulin, Isophane, Insulin, Long-Acting, Live Birth, Pregnancy, Pregnancy Outcome, Pregnancy in Diabetics, Pregnancy, Ectopic",
author = "Moshe Hod and Mathiesen, {Elisabeth R} and Lois Jovanovi{\v c} and McCance, {David R} and Marina Ivanisevic and Santiago Dur{\'a}n-Garcia and Lise Br{\o}ndsted and Avideh Nazeri and Peter Damm",
year = "2014",
month = jan,
doi = "10.3109/14767058.2013.799650",
language = "English",
volume = "27",
pages = "7--13",
journal = "Journal of Maternal-Fetal Medicine",
issn = "1476-7058",
publisher = "Taylor & Francis",
number = "1",

}

RIS

TY - JOUR

T1 - A randomized trial comparing perinatal outcomes using insulin detemir or neutral protamine Hagedorn in type 1 diabetes

AU - Hod, Moshe

AU - Mathiesen, Elisabeth R

AU - Jovanovič, Lois

AU - McCance, David R

AU - Ivanisevic, Marina

AU - Durán-Garcia, Santiago

AU - Brøndsted, Lise

AU - Nazeri, Avideh

AU - Damm, Peter

PY - 2014/1

Y1 - 2014/1

N2 - OBJECTIVE: This randomized controlled trial aimed to compare the efficacy and safety of insulin detemir (IDet) with neutral protamine Hagedorn (NPH), both with insulin aspart, in pregnant women with type 1 diabetes. The perinatal and obstetric pregnancy outcomes are presented.METHODS: Subjects were randomized to IDet (n = 152) or NPH (n = 158) ≤12 months before pregnancy or at 8-12 gestational weeks.RESULTS: For IDet and NPH, there were 128 and 136 live births, 11 and 9 early fetal losses, and two and one perinatal deaths, respectively. Gestational age at delivery was greater for children from the IDet arm than the NPH arm (treatment difference: 0.49 weeks [95% CI 0.11;0.88], p = 0.012, linear regression). Sixteen children had a malformation (IDet: n = 8/142, 5.6%; NPH: n = 8/145, 5.5%). The incidence of adverse events was similar between treatments.CONCLUSION: IDet is as well tolerated as NPH as regards perinatal outcomes in pregnant women with type 1 diabetes and no safety issues were identified.

AB - OBJECTIVE: This randomized controlled trial aimed to compare the efficacy and safety of insulin detemir (IDet) with neutral protamine Hagedorn (NPH), both with insulin aspart, in pregnant women with type 1 diabetes. The perinatal and obstetric pregnancy outcomes are presented.METHODS: Subjects were randomized to IDet (n = 152) or NPH (n = 158) ≤12 months before pregnancy or at 8-12 gestational weeks.RESULTS: For IDet and NPH, there were 128 and 136 live births, 11 and 9 early fetal losses, and two and one perinatal deaths, respectively. Gestational age at delivery was greater for children from the IDet arm than the NPH arm (treatment difference: 0.49 weeks [95% CI 0.11;0.88], p = 0.012, linear regression). Sixteen children had a malformation (IDet: n = 8/142, 5.6%; NPH: n = 8/145, 5.5%). The incidence of adverse events was similar between treatments.CONCLUSION: IDet is as well tolerated as NPH as regards perinatal outcomes in pregnant women with type 1 diabetes and no safety issues were identified.

KW - Abortion, Induced

KW - Abortion, Spontaneous

KW - Congenital Abnormalities

KW - Diabetes Mellitus, Type 1

KW - Drug Combinations

KW - Female

KW - Fetal Death

KW - Gestational Age

KW - Humans

KW - Hypoglycemic Agents

KW - Insulin Aspart

KW - Insulin, Isophane

KW - Insulin, Long-Acting

KW - Live Birth

KW - Pregnancy

KW - Pregnancy Outcome

KW - Pregnancy in Diabetics

KW - Pregnancy, Ectopic

U2 - 10.3109/14767058.2013.799650

DO - 10.3109/14767058.2013.799650

M3 - Journal article

C2 - 23617228

VL - 27

SP - 7

EP - 13

JO - Journal of Maternal-Fetal Medicine

JF - Journal of Maternal-Fetal Medicine

SN - 1476-7058

IS - 1

ER -

ID: 138421739