TY - JOUR

T1 - Effect of Influenza Vaccination on Risk of Coronavirus Disease 2019

T2 - A Prospective Cohort Study of 46 000 Healthcare Workers( )

AU - Kristensen, Jonas Henrik

AU - Hasselbalch, Rasmus Bo

AU - Pries-Heje, Mia

AU - Nielsen, Pernille Brok

AU - Knudsen, Andreas Dehlbaek

AU - Fogh, Kamille

AU - Norsk, Jakob Boesgaard

AU - Eiken, Aleksander

AU - Andersen, Ove

AU - Fischer, Thea Kølsen

AU - Jensen, Claus Antonio Juul

AU - Torp-Pedersen, Christian

AU - Rungby, Jørgen

AU - Ditlev, Sisse Bolm

AU - Hageman, Ida

AU - Mogelvang, Rasmus

AU - Gybel-Brask, Mikkel

AU - Dessau, Ram Benny

AU - Sørensen, Erik

AU - Harritshøj, Lene

AU - Folke, Fredrik

AU - Moller, Maria Elizabeth Engel

AU - Benfield, Thomas

AU - Ullum, Henrik

AU - Jorgensen, Charlotte Svaerke

AU - Ostrowski, Sisse Rye

AU - Nielsen, Susanne Dam

AU - Bundgaard, Henning

AU - Iversen, Kasper

PY - 2022

Y1 - 2022

N2 - Background The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19). Methods A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination. Results The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found. Conclusions The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.This cohort study of 46 112 healthcare workers examined the effect of influenza vaccination on hospitalization and symptoms due to COVID-19 and development of antibodies against SARS-CoV-2. Influenza vaccination had no effect on the specified outcomes.

AB - Background The purpose of this study was to assess whether influenza vaccination has an impact on the risk of coronavirus disease 2019 (COVID-19). Methods A cohort of 46 112 healthcare workers were tested for antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and filled in a survey on COVID-19 symptoms, hospitalization, and influenza vaccination. Results The risk ratio of hospitalization due to SARS-CoV-2 for influenza vaccinated compared with unvaccinated participants was 1.00 for the seasonal vaccination in 2019/2020 (confidence interval, .56-1.78, P = 1.00). Likewise, no clinical effect of influenza vaccination on development of antibodies against SARS-CoV-2 was found. Conclusions The present findings indicate that influenza vaccination does not affect the risk of SARS-CoV-2 infection or COVID-19.This cohort study of 46 112 healthcare workers examined the effect of influenza vaccination on hospitalization and symptoms due to COVID-19 and development of antibodies against SARS-CoV-2. Influenza vaccination had no effect on the specified outcomes.

KW - cohort study

KW - COVID-19

KW - healthcare workers

KW - influenza vaccination

KW - SARS-CoV-2

U2 - 10.1093/infdis/jiac001

DO - 10.1093/infdis/jiac001

M3 - Journal article

C2 - 34989811

VL - 226

SP - 6

EP - 10

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 1

ER -