Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation

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Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries : 23 million person-years of observation. / Emerging Risk Factors Collaboration.

I: The Lancet Diabetes and Endocrinology, Bind 11, Nr. 10, 2023, s. 731-742.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Emerging Risk Factors Collaboration 2023, 'Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation', The Lancet Diabetes and Endocrinology, bind 11, nr. 10, s. 731-742. https://doi.org/10.1016/S2213-8587(23)00223-1

APA

Emerging Risk Factors Collaboration (2023). Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation. The Lancet Diabetes and Endocrinology, 11(10), 731-742. https://doi.org/10.1016/S2213-8587(23)00223-1

Vancouver

Emerging Risk Factors Collaboration. Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation. The Lancet Diabetes and Endocrinology. 2023;11(10):731-742. https://doi.org/10.1016/S2213-8587(23)00223-1

Author

Emerging Risk Factors Collaboration. / Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries : 23 million person-years of observation. I: The Lancet Diabetes and Endocrinology. 2023 ; Bind 11, Nr. 10. s. 731-742.

Bibtex

@article{eb42314e4d744314a954800017a53541,
title = "Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries: 23 million person-years of observation",
abstract = "Background: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of the associations between age at diagnosis of diabetes and all-cause mortality, cause-specific mortality, and reductions in life expectancy. Methods: For this observational study, we conducted a combined analysis of individual-participant data from 19 high-income countries using two large-scale data sources: the Emerging Risk Factors Collaboration (96 cohorts, median baseline years 1961–2007, median latest follow-up years 1980–2013) and the UK Biobank (median baseline year 2006, median latest follow-up year 2020). We calculated age-adjusted and sex-adjusted hazard ratios (HRs) for all-cause mortality according to age at diagnosis of diabetes using data from 1 515 718 participants, in whom deaths were recorded during 23·1 million person-years of follow-up. We estimated cumulative survival by applying age-specific HRs to age-specific death rates from 2015 for the USA and the EU. Findings: For participants with diabetes, we observed a linear dose–response association between earlier age at diagnosis and higher risk of all-cause mortality compared with participants without diabetes. HRs were 2·69 (95% CI 2·43–2·97) when diagnosed at 30–39 years, 2·26 (2·08–2·45) at 40–49 years, 1·84 (1·72–1·97) at 50–59 years, 1·57 (1·47–1·67) at 60–69 years, and 1·39 (1·29–1·51) at 70 years and older. HRs per decade of earlier diagnosis were similar for men and women. Using death rates from the USA, a 50-year-old individual with diabetes died on average 14 years earlier when diagnosed aged 30 years, 10 years earlier when diagnosed aged 40 years, or 6 years earlier when diagnosed aged 50 years than an individual without diabetes. Using EU death rates, the corresponding estimates were 13, 9, or 5 years earlier. Interpretation: Every decade of earlier diagnosis of diabetes was associated with about 3–4 years of lower life expectancy, highlighting the need to develop and implement interventions that prevent or delay the onset of diabetes and to intensify the treatment of risk factors among young adults diagnosed with diabetes. Funding: British Heart Foundation, Medical Research Council, National Institute for Health and Care Research, and Health Data Research UK.",
author = "S. Kaptoge and Seshasai, {S. R.K.} and L. Sun and M. Walker and T. Bolton and S. Spackman and F. Ataklte and P. Willeit and S. Bell and S. Burgess and L. Pennells and S. Altay and G. Assmann and Y. Ben-Shlomo and Best, {L. G.} and C. Bj{\"o}rkelund and Blazer, {D. G.} and H. Brenner and Brunner, {E. J.} and Dagenais, {G. R.} and Cooper, {J. A.} and C. Cooper and Crespo, {C. J.} and M. Cushman and D'Agostino, {R. B.} and M. Daimon and Daniels, {L. B.} and R. Danker and Davidson, {K. W.} and {de Jongh}, {R. T.} and C. Donfrancesco and P. Ducimetiere and Elders, {P. J.M.} and G. Engstr{\"o}m and I. Ford and I. Gallacher and Bakker, {S. J.L.} and U. Goldbourt and {de La C{\'a}mara}, G. and S. Grimsgaard and V. Gudnason and Hansson, {P. O.} and H. Imano and Jukema, {J. W.} and C. Kabrhel and J. Kauhanen and Nordestgaard, {B. G.} and A. Rosengren and I. Nj{\o}lstad and E. Mathiesen and {Emerging Risk Factors Collaboration}",
note = "Publisher Copyright: {\textcopyright} 2023",
year = "2023",
doi = "10.1016/S2213-8587(23)00223-1",
language = "English",
volume = "11",
pages = "731--742",
journal = "The Lancet Diabetes & Endocrinology",
issn = "2213-8587",
publisher = "The Lancet Publishing Group",
number = "10",

}

RIS

TY - JOUR

T1 - Life expectancy associated with different ages at diagnosis of type 2 diabetes in high-income countries

T2 - 23 million person-years of observation

AU - Kaptoge, S.

AU - Seshasai, S. R.K.

AU - Sun, L.

AU - Walker, M.

AU - Bolton, T.

AU - Spackman, S.

AU - Ataklte, F.

AU - Willeit, P.

AU - Bell, S.

AU - Burgess, S.

AU - Pennells, L.

AU - Altay, S.

AU - Assmann, G.

AU - Ben-Shlomo, Y.

AU - Best, L. G.

AU - Björkelund, C.

AU - Blazer, D. G.

AU - Brenner, H.

AU - Brunner, E. J.

AU - Dagenais, G. R.

AU - Cooper, J. A.

AU - Cooper, C.

AU - Crespo, C. J.

AU - Cushman, M.

AU - D'Agostino, R. B.

AU - Daimon, M.

AU - Daniels, L. B.

AU - Danker, R.

AU - Davidson, K. W.

AU - de Jongh, R. T.

AU - Donfrancesco, C.

AU - Ducimetiere, P.

AU - Elders, P. J.M.

AU - Engström, G.

AU - Ford, I.

AU - Gallacher, I.

AU - Bakker, S. J.L.

AU - Goldbourt, U.

AU - de La Cámara, G.

AU - Grimsgaard, S.

AU - Gudnason, V.

AU - Hansson, P. O.

AU - Imano, H.

AU - Jukema, J. W.

AU - Kabrhel, C.

AU - Kauhanen, J.

AU - Nordestgaard, B. G.

AU - Rosengren, A.

AU - Njølstad, I.

AU - Mathiesen, E.

AU - Emerging Risk Factors Collaboration

N1 - Publisher Copyright: © 2023

PY - 2023

Y1 - 2023

N2 - Background: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of the associations between age at diagnosis of diabetes and all-cause mortality, cause-specific mortality, and reductions in life expectancy. Methods: For this observational study, we conducted a combined analysis of individual-participant data from 19 high-income countries using two large-scale data sources: the Emerging Risk Factors Collaboration (96 cohorts, median baseline years 1961–2007, median latest follow-up years 1980–2013) and the UK Biobank (median baseline year 2006, median latest follow-up year 2020). We calculated age-adjusted and sex-adjusted hazard ratios (HRs) for all-cause mortality according to age at diagnosis of diabetes using data from 1 515 718 participants, in whom deaths were recorded during 23·1 million person-years of follow-up. We estimated cumulative survival by applying age-specific HRs to age-specific death rates from 2015 for the USA and the EU. Findings: For participants with diabetes, we observed a linear dose–response association between earlier age at diagnosis and higher risk of all-cause mortality compared with participants without diabetes. HRs were 2·69 (95% CI 2·43–2·97) when diagnosed at 30–39 years, 2·26 (2·08–2·45) at 40–49 years, 1·84 (1·72–1·97) at 50–59 years, 1·57 (1·47–1·67) at 60–69 years, and 1·39 (1·29–1·51) at 70 years and older. HRs per decade of earlier diagnosis were similar for men and women. Using death rates from the USA, a 50-year-old individual with diabetes died on average 14 years earlier when diagnosed aged 30 years, 10 years earlier when diagnosed aged 40 years, or 6 years earlier when diagnosed aged 50 years than an individual without diabetes. Using EU death rates, the corresponding estimates were 13, 9, or 5 years earlier. Interpretation: Every decade of earlier diagnosis of diabetes was associated with about 3–4 years of lower life expectancy, highlighting the need to develop and implement interventions that prevent or delay the onset of diabetes and to intensify the treatment of risk factors among young adults diagnosed with diabetes. Funding: British Heart Foundation, Medical Research Council, National Institute for Health and Care Research, and Health Data Research UK.

AB - Background: The prevalence of type 2 diabetes is increasing rapidly, particularly among younger age groups. Estimates suggest that people with diabetes die, on average, 6 years earlier than people without diabetes. We aimed to provide reliable estimates of the associations between age at diagnosis of diabetes and all-cause mortality, cause-specific mortality, and reductions in life expectancy. Methods: For this observational study, we conducted a combined analysis of individual-participant data from 19 high-income countries using two large-scale data sources: the Emerging Risk Factors Collaboration (96 cohorts, median baseline years 1961–2007, median latest follow-up years 1980–2013) and the UK Biobank (median baseline year 2006, median latest follow-up year 2020). We calculated age-adjusted and sex-adjusted hazard ratios (HRs) for all-cause mortality according to age at diagnosis of diabetes using data from 1 515 718 participants, in whom deaths were recorded during 23·1 million person-years of follow-up. We estimated cumulative survival by applying age-specific HRs to age-specific death rates from 2015 for the USA and the EU. Findings: For participants with diabetes, we observed a linear dose–response association between earlier age at diagnosis and higher risk of all-cause mortality compared with participants without diabetes. HRs were 2·69 (95% CI 2·43–2·97) when diagnosed at 30–39 years, 2·26 (2·08–2·45) at 40–49 years, 1·84 (1·72–1·97) at 50–59 years, 1·57 (1·47–1·67) at 60–69 years, and 1·39 (1·29–1·51) at 70 years and older. HRs per decade of earlier diagnosis were similar for men and women. Using death rates from the USA, a 50-year-old individual with diabetes died on average 14 years earlier when diagnosed aged 30 years, 10 years earlier when diagnosed aged 40 years, or 6 years earlier when diagnosed aged 50 years than an individual without diabetes. Using EU death rates, the corresponding estimates were 13, 9, or 5 years earlier. Interpretation: Every decade of earlier diagnosis of diabetes was associated with about 3–4 years of lower life expectancy, highlighting the need to develop and implement interventions that prevent or delay the onset of diabetes and to intensify the treatment of risk factors among young adults diagnosed with diabetes. Funding: British Heart Foundation, Medical Research Council, National Institute for Health and Care Research, and Health Data Research UK.

U2 - 10.1016/S2213-8587(23)00223-1

DO - 10.1016/S2213-8587(23)00223-1

M3 - Journal article

C2 - 37708900

AN - SCOPUS:85171970811

VL - 11

SP - 731

EP - 742

JO - The Lancet Diabetes & Endocrinology

JF - The Lancet Diabetes & Endocrinology

SN - 2213-8587

IS - 10

ER -

ID: 389548869