Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation. / Hausmann, Annika; Steenholdt, Casper; Nielsen, Ole H.; Jensen, Kim B.

I: Trends in Molecular Medicine, Bind 30, Nr. 3, 2024, s. 239-251.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Hausmann, A, Steenholdt, C, Nielsen, OH & Jensen, KB 2024, 'Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation', Trends in Molecular Medicine, bind 30, nr. 3, s. 239-251. https://doi.org/10.1016/j.molmed.2024.01.001

APA

Hausmann, A., Steenholdt, C., Nielsen, O. H., & Jensen, K. B. (2024). Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation. Trends in Molecular Medicine, 30(3), 239-251. https://doi.org/10.1016/j.molmed.2024.01.001

Vancouver

Hausmann A, Steenholdt C, Nielsen OH, Jensen KB. Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation. Trends in Molecular Medicine. 2024;30(3):239-251. https://doi.org/10.1016/j.molmed.2024.01.001

Author

Hausmann, Annika ; Steenholdt, Casper ; Nielsen, Ole H. ; Jensen, Kim B. / Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation. I: Trends in Molecular Medicine. 2024 ; Bind 30, Nr. 3. s. 239-251.

Bibtex

@article{82aa00892c2a48a6a164a0871ae34b88,

title = "Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation",

abstract = "The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically target inflammatory mediators and have led to improvement of clinical outcomes; however, a significant proportion of patients experience treatment failure. Pro-repair effects of inflammatory mediators on the epithelium are emerging. In this review we summarize current knowledge on involved epithelial pathways, identify open questions, and put recent findings into clinical perspective, and pro-repair effects. A detailed understanding of epithelial pathways integrating mucosal stimuli in homeostasis and inflammation is crucial for the development of novel, more targeted therapies.",

author = "Annika Hausmann and Casper Steenholdt and Nielsen, {Ole H.} and Jensen, {Kim B.}",

year = "2024",

doi = "10.1016/j.molmed.2024.01.001",

language = "English",

volume = "30",

pages = "239--251",

journal = "Trends in Molecular Medicine",

issn = "1471-4914",

publisher = "Elsevier Ltd. * Trends Journals",

number = "3",

}

RIS

TY - JOUR

T1 - Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation

AU - Hausmann, Annika

AU - Steenholdt, Casper

AU - Nielsen, Ole H.

AU - Jensen, Kim B.

PY - 2024

Y1 - 2024

N2 - The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically target inflammatory mediators and have led to improvement of clinical outcomes; however, a significant proportion of patients experience treatment failure. Pro-repair effects of inflammatory mediators on the epithelium are emerging. In this review we summarize current knowledge on involved epithelial pathways, identify open questions, and put recent findings into clinical perspective, and pro-repair effects. A detailed understanding of epithelial pathways integrating mucosal stimuli in homeostasis and inflammation is crucial for the development of novel, more targeted therapies.

AB - The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its impairment contributes to the pathogenesis of inflammatory bowel disease (IBD), a chronic inflammatory condition affecting more than seven million people worldwide. Current treatment options specifically target inflammatory mediators and have led to improvement of clinical outcomes; however, a significant proportion of patients experience treatment failure. Pro-repair effects of inflammatory mediators on the epithelium are emerging. In this review we summarize current knowledge on involved epithelial pathways, identify open questions, and put recent findings into clinical perspective, and pro-repair effects. A detailed understanding of epithelial pathways integrating mucosal stimuli in homeostasis and inflammation is crucial for the development of novel, more targeted therapies.

U2 - 10.1016/j.molmed.2024.01.001

DO - 10.1016/j.molmed.2024.01.001

M3 - Review

C2 - 38320941

VL - 30

SP - 239

EP - 251

JO - Trends in Molecular Medicine

JF - Trends in Molecular Medicine

SN - 1471-4914

IS - 3

ER -

ID: 381789356

Institut for Klinisk Medicin