Managing vitamin D deficiency in inflammatory bowel disease
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Managing vitamin D deficiency in inflammatory bowel disease
Forlagets udgivne version, 835 KB, PDF-dokument
Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.
Originalsprog | Engelsk |
---|---|
Artikelnummer | 31656565 |
Tidsskrift | Frontline Gastroenterology |
Vol/bind | 10 |
Udgave nummer | 4 |
Sider (fra-til) | 394-400 |
Antal sider | 7 |
ISSN | 2041-4137 |
DOI | |
Status | Udgivet - 2019 |
Antal downloads er baseret på statistik fra Google Scholar og www.ku.dk
ID: 212562347