Therapeutic drug monitoring in inflammatory bowel disease: implementation, utilization, and barriers in clinical practice in Scandinavia
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Therapeutic drug monitoring in inflammatory bowel disease : implementation, utilization, and barriers in clinical practice in Scandinavia. / Bjørlykke, Kristin H.; Jahnsen, Jørgen; Brynskov, Jørn; Molander, Pauliina; Eberhardson, Michael; Davidsdottir, Loà G.; Sipponen, Taina; Hjortswang, Henrik; Goll, Guro Løvik; Syversen, Silje Watterdal; Langholz, Ebbe; Jørgensen, Kristin K.; Steenholdt, Casper.
I: Scandinavian Journal of Gastroenterology, Bind 58, Nr. 1, 2023, s. 25-33.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Therapeutic drug monitoring in inflammatory bowel disease
T2 - implementation, utilization, and barriers in clinical practice in Scandinavia
AU - Bjørlykke, Kristin H.
AU - Jahnsen, Jørgen
AU - Brynskov, Jørn
AU - Molander, Pauliina
AU - Eberhardson, Michael
AU - Davidsdottir, Loà G.
AU - Sipponen, Taina
AU - Hjortswang, Henrik
AU - Goll, Guro Løvik
AU - Syversen, Silje Watterdal
AU - Langholz, Ebbe
AU - Jørgensen, Kristin K.
AU - Steenholdt, Casper
N1 - Publisher Copyright: © 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
PY - 2023
Y1 - 2023
N2 - Background and aims: Therapeutic drug monitoring (TDM) may optimize biologic and thiopurine therapies in inflammatory bowel disease (IBD). The study aimed to investigate implementation and utilization of TDM in Scandinavia. Methods: A web-based questionnaire on the use of TDM was distributed to Scandinavian gastroenterologists via the national societies. Results: In total, 297 IBD physicians prescribing biologic therapies, equally distributed between community and university hospitals, were included (response rate 42%) (Norway 118 (40%), Denmark 86 (29%), Sweden 50 (17%), Finland 33 (11%), Iceland 10 (3%)). Overall, TDM was applied during biologic therapies by 87%, and for TNF-inhibitors >90%. Among the users, reactive and proactive TDM were utilized by 90% and 63%, respectively. Danish physicians were significantly less inclined to use TDM compared to other Scandinavian countries; (58% vs 98%); OR 0.03 [0.01–0.09], p < 0.001). Reactive TDM was commonly applied at primary (74%) and secondary (99%) treatment failure. Proactive TDM was used by 80% during maintenance therapy and 56% during induction and more commonly utilized in Norway (p < 0.001), and by physicians managing >10 IBD patients/week (p = 0.005). TDM scenarios were interpreted in accord with available evidence but with discrepancies for proactive TDM. The main barriers to TDM were lack of guidelines (51%) and time lag between sampling and results (49%). TDM of thiopurines was routinely used by 87%. Conclusion: TDM of biologic and thiopurine therapies has been broadly implemented into clinical practice in Scandinavia. However, physicians call for TDM guidelines detailing indications and interpretations of test results along with improved test response times.
AB - Background and aims: Therapeutic drug monitoring (TDM) may optimize biologic and thiopurine therapies in inflammatory bowel disease (IBD). The study aimed to investigate implementation and utilization of TDM in Scandinavia. Methods: A web-based questionnaire on the use of TDM was distributed to Scandinavian gastroenterologists via the national societies. Results: In total, 297 IBD physicians prescribing biologic therapies, equally distributed between community and university hospitals, were included (response rate 42%) (Norway 118 (40%), Denmark 86 (29%), Sweden 50 (17%), Finland 33 (11%), Iceland 10 (3%)). Overall, TDM was applied during biologic therapies by 87%, and for TNF-inhibitors >90%. Among the users, reactive and proactive TDM were utilized by 90% and 63%, respectively. Danish physicians were significantly less inclined to use TDM compared to other Scandinavian countries; (58% vs 98%); OR 0.03 [0.01–0.09], p < 0.001). Reactive TDM was commonly applied at primary (74%) and secondary (99%) treatment failure. Proactive TDM was used by 80% during maintenance therapy and 56% during induction and more commonly utilized in Norway (p < 0.001), and by physicians managing >10 IBD patients/week (p = 0.005). TDM scenarios were interpreted in accord with available evidence but with discrepancies for proactive TDM. The main barriers to TDM were lack of guidelines (51%) and time lag between sampling and results (49%). TDM of thiopurines was routinely used by 87%. Conclusion: TDM of biologic and thiopurine therapies has been broadly implemented into clinical practice in Scandinavia. However, physicians call for TDM guidelines detailing indications and interpretations of test results along with improved test response times.
KW - antibodies
KW - biologics
KW - clinical implementation
KW - drug levels
KW - Therapeutic drug monitoring
U2 - 10.1080/00365521.2022.2108684
DO - 10.1080/00365521.2022.2108684
M3 - Journal article
C2 - 35996928
AN - SCOPUS:85136529247
VL - 58
SP - 25
EP - 33
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 1
ER -
ID: 321642515