Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People with Human Immunodeficiency Virus and Well-Controlled Viral Replication
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Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People with Human Immunodeficiency Virus and Well-Controlled Viral Replication. / Akdag, Delal; Knudsen, Andreas Dehlbæk; Thudium, Rebekka Faber; Kirkegaard-Klitbo, Ditte Marie; Nielsen, Chivit; Brown, Peter; Afzal, Shoaib; Nordestgaard, Børge G.; Lundgren, Jens; Nielsen, Susanne Dam.
I: Journal of Infectious Diseases, Bind 220, Nr. 11, 2019, s. 1834-1842.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Increased Risk of Anemia, Neutropenia, and Thrombocytopenia in People with Human Immunodeficiency Virus and Well-Controlled Viral Replication
AU - Akdag, Delal
AU - Knudsen, Andreas Dehlbæk
AU - Thudium, Rebekka Faber
AU - Kirkegaard-Klitbo, Ditte Marie
AU - Nielsen, Chivit
AU - Brown, Peter
AU - Afzal, Shoaib
AU - Nordestgaard, Børge G.
AU - Lundgren, Jens
AU - Nielsen, Susanne Dam
PY - 2019
Y1 - 2019
N2 - Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Methods: PWH with undetectable viral replication and absence of chronic hepatitis infection (n = 796) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n = 2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and high-sensitivity C-reactive protein were performed to determine possible associations between HIV and cytopenias. Results: PWH had a higher prevalence of anemia (6.9% vs 3.4%, P <. 001), neutropenia (1.3% vs 0.2%, P <. 001), and thrombocytopenia (5.5% vs 2.7%, P <. 001) compared with uninfected controls. HIV was independently associated with anemia-Adjusted odds ratio (aOR) of 2.0 (95% confidence interval [CI], 1.4-3.0); neutropenia aOR, 6.3 (95% CI, 2.0-19.6); and thrombocytopenia aOR, 2.7 (95% CI, 1.8-4.2). No association was found between HIV and lymphocytopenia. Conclusions: Cytopenia is rare in people with well-controlled HIV, but HIV remains a risk factor for anemia, neutropenia, and thrombocytopenia and requires ongoing attention and monitoring.
AB - Background: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with human immunodeficiency virus (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia. Methods: PWH with undetectable viral replication and absence of chronic hepatitis infection (n = 796) were recruited from the Copenhagen Comorbidity in HIV Infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n = 2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and high-sensitivity C-reactive protein were performed to determine possible associations between HIV and cytopenias. Results: PWH had a higher prevalence of anemia (6.9% vs 3.4%, P <. 001), neutropenia (1.3% vs 0.2%, P <. 001), and thrombocytopenia (5.5% vs 2.7%, P <. 001) compared with uninfected controls. HIV was independently associated with anemia-Adjusted odds ratio (aOR) of 2.0 (95% confidence interval [CI], 1.4-3.0); neutropenia aOR, 6.3 (95% CI, 2.0-19.6); and thrombocytopenia aOR, 2.7 (95% CI, 1.8-4.2). No association was found between HIV and lymphocytopenia. Conclusions: Cytopenia is rare in people with well-controlled HIV, but HIV remains a risk factor for anemia, neutropenia, and thrombocytopenia and requires ongoing attention and monitoring.
KW - Anemia
KW - Cytopenia
KW - HIV
KW - Lymphocytopenia
KW - Neutropenia
KW - Thrombocytopenia
U2 - 10.1093/infdis/jiz394
DO - 10.1093/infdis/jiz394
M3 - Journal article
C2 - 31414119
AN - SCOPUS:85073663199
VL - 220
SP - 1834
EP - 1842
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 11
ER -
ID: 235780010