Systems biology of neutrophil differentiation and immune response.
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Systems biology of neutrophil differentiation and immune response. / Theilgaard-Mönch, Kim; Porse, Bo T; Borregaard, Niels.
I: Current Opinion in Immunology, Bind 18, Nr. 1, 2005, s. 54-60.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Systems biology of neutrophil differentiation and immune response.
AU - Theilgaard-Mönch, Kim
AU - Porse, Bo T
AU - Borregaard, Niels
N1 - Keywords: Animals; Cell Cycle; Cell Differentiation; Eosinophil Granule Proteins; Humans; Immunity, Natural; Immunologic Factors; Neutrophils; Systems Biology
PY - 2005
Y1 - 2005
N2 - Systems biology has emerged as a new scientific field, which aims at investigating biological processes at the genomic and proteomic levels. Recent studies have unravelled aspects of neutrophil differentiation and immune responses at the systems level using high-throughput technologies. These studies have identified a plethora of novel effector proteins stored in the granules of neutrophils. In addition, these studies provide evidence that neutrophil differentiation and immune response are governed by a highly coordinated transcriptional programme that regulates cellular fate and function in a context-dependent manner.
AB - Systems biology has emerged as a new scientific field, which aims at investigating biological processes at the genomic and proteomic levels. Recent studies have unravelled aspects of neutrophil differentiation and immune responses at the systems level using high-throughput technologies. These studies have identified a plethora of novel effector proteins stored in the granules of neutrophils. In addition, these studies provide evidence that neutrophil differentiation and immune response are governed by a highly coordinated transcriptional programme that regulates cellular fate and function in a context-dependent manner.
U2 - 10.1016/j.coi.2005.11.010
DO - 10.1016/j.coi.2005.11.010
M3 - Journal article
C2 - 16343884
VL - 18
SP - 54
EP - 60
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
SN - 0952-7915
IS - 1
ER -
ID: 5140609