Analysis of Neutralization Titers against SARS-CoV-2 in Health-Care Workers Vaccinated with Prime-Boost mRNA–mRNA or Vector–mRNA COVID-19 Vaccines
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With increasing numbers of vaccine-breakthrough infections worldwide, assessing the immunogenicity of vaccinated health-care workers that are frequently exposed to SARS-CoV-2-infected individuals is important. In this study, neutralization titers against SARS-CoV-2 were assessed one month after completed prime-boost vaccine regimens in health-care workers vaccinated with either mRNA–mRNA (Comirnaty®, BioNTech-Pfzier, Mainz, Germany/New York, NY, USA, n = 98) or vector-based (Vaxzevria®, Oxford-AstraZeneca, Cambridge, UK) followed by mRNA-based (Comirnaty® or Spikevax®, Moderna, Cambridge, MA, USA) vaccines (n = 16). Vaccine-induced neutralization titers were compared to time-matched, unvaccinated individuals that were infected with SARS-CoV-2 and presented with mild symptoms (n = 38). Significantly higher neutralizing titers were found in both the mRNA–mRNA (ID50: 2525, IQR: 1667–4313) and vector–mRNA (ID50: 4978, IQR: 3364–7508) prime-boost vaccine regimens when compared to SARS-CoV-2 infection (ID50: 401, IQR: 271–792) (p < 0.0001). However, infection with SARS-CoV-2 induced higher titers when compared to a single dose of Vaxzevria® (p = 0.0072). Between mRNA–mRNA and vector– mRNA prime-boost regimens, the vector–mRNA vaccine regimen induced higher neutralization titers (p = 0.0054). Demographically, both age and time between vaccination doses were associated with vaccine-induced neutralization titers (p = 0.02 and p = 0.03, respectively). This warrants further investigation into the optimal time to administer booster vaccination for optimized induction of neutralizing responses. Although anecdotal (n = 3), those with exposure to SARS-CoV-2, either before or after vaccination, demonstrated superior neutralizing titers, which is suggestive of further boosting through viral exposure.
Originalsprog | Engelsk |
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Artikelnummer | 75 |
Tidsskrift | Vaccines |
Vol/bind | 10 |
Udgave nummer | 1 |
ISSN | 2076-393X |
DOI | |
Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
This work was supported by grants from The Capital Region of Denmark?s Research Foundation (C.S., J.B.; 2020-A6936 and 2019-A6720), the Novo Nordisk Foundation (N.W., J.B.; NNF19OC0054518 and NNF19OC0055462), the Independent Research Fund Denmark (J.B.; 8020-00391B), the Candys Foundation (C.F-A., S.R., J.B.; 2018-269), The Danish Cancer Society (J.B.; R204-A12639), Manufacturer Vilhelm Pedersen and wife?s memorial scholarship (S.B), Master carpenter J?rgen Holm and wife Elisa. F. Hansen?s memorial scholarship (S.B.; 20006-1948) and the Danish Agency for Science and Higher Education (S.R., J.B.; 0237-00005B). J.B. is the 2015 recipient of the Novo Nordisk Prize and the 2019 recipient of a Distinguished Investigator grant from the Novo Nordisk Foundation.
Funding Information:
Funding: This work was supported by grants from The Capital Region of Denmark’s Research Foundation (C.S., J.B.; 2020-A6936 and 2019-A6720), the Novo Nordisk Foundation (N.W., J.B.; NNF19OC0054518 and NNF19OC0055462), the Independent Research Fund Denmark (J.B.; 8020-00391B), the Candys Foundation (C.F-A., S.R., J.B.; 2018-269), The Danish Cancer Society (J.B.; R204-A12639), Manufacturer Vilhelm Pedersen and wife’s memorial scholarship (S.B), Master carpenter Jørgen Holm and wife Elisa. F. Hansen’s memorial scholarship (S.B.; 20006-1948) and the Danish Agency for Science and Higher Education (S.R., J.B.; 0237-00005B). J.B. is the 2015 recipient of the Novo Nordisk Prize and the 2019 recipient of a Distinguished Investigator grant from the Novo Nordisk Foundation.
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© 2022 by the authors. Licensee MDPI, Basel, Switzerland.
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