Associations between invasive aspergillosis and cytomegalovirus in lung transplant recipients: a nationwide cohort study
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Associations between invasive aspergillosis and cytomegalovirus in lung transplant recipients : a nationwide cohort study. / Wulff, Signe Marie; Perch, Michael; Helweg-Larsen, Jannik; Bredahl, Pia; Arendrup, Maiken Cavling; Lundgren, Jens; Helleberg, Marie; Crone, Cornelia Geisler.
I: APMIS, Bind 131, Nr. 11, 2023, s. 574-583.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Associations between invasive aspergillosis and cytomegalovirus in lung transplant recipients
T2 - a nationwide cohort study
AU - Wulff, Signe Marie
AU - Perch, Michael
AU - Helweg-Larsen, Jannik
AU - Bredahl, Pia
AU - Arendrup, Maiken Cavling
AU - Lundgren, Jens
AU - Helleberg, Marie
AU - Crone, Cornelia Geisler
N1 - Publisher Copyright: © 2023 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.
PY - 2023
Y1 - 2023
N2 - Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause morbidity among lung transplant recipients (LTXr). Early diagnosis and treatment could improve outcomes. We examined rates of CMV after IA and vice versa to assess whether screening for one infection is warranted after detecting the other. All Danish LTXr, 2010–2019, were followed for IA and CMV for 2 years after transplantation. IA was defined using ISHLT criteria. Adjusted incidence rate ratios (aIRR) were estimated by Poisson regression adjusted for time after transplantation. We included 295 LTXr, among whom CMV and IA were diagnosed in 128 (43%) and 48 (16%). The risk of CMV was high the first 3 months after IA, IR 98/100 person-years of follow-up (95% CI 47–206). The risk of IA was significantly increased in the first 3 months after CMV, aIRR 2.91 (95% CI 1.32–6.44). Numbers needed to screen to diagnose one case of CMV after IA, and one case of IA after CMV was approximately seven and eight, respectively. Systematic screening for CMV following diagnosis of IA, and vice versa, may improve timeliness of diagnosis and outcomes for LTXr.
AB - Cytomegalovirus (CMV) and invasive aspergillosis (IA) cause morbidity among lung transplant recipients (LTXr). Early diagnosis and treatment could improve outcomes. We examined rates of CMV after IA and vice versa to assess whether screening for one infection is warranted after detecting the other. All Danish LTXr, 2010–2019, were followed for IA and CMV for 2 years after transplantation. IA was defined using ISHLT criteria. Adjusted incidence rate ratios (aIRR) were estimated by Poisson regression adjusted for time after transplantation. We included 295 LTXr, among whom CMV and IA were diagnosed in 128 (43%) and 48 (16%). The risk of CMV was high the first 3 months after IA, IR 98/100 person-years of follow-up (95% CI 47–206). The risk of IA was significantly increased in the first 3 months after CMV, aIRR 2.91 (95% CI 1.32–6.44). Numbers needed to screen to diagnose one case of CMV after IA, and one case of IA after CMV was approximately seven and eight, respectively. Systematic screening for CMV following diagnosis of IA, and vice versa, may improve timeliness of diagnosis and outcomes for LTXr.
KW - aspergillosis
KW - Aspergillus
KW - cytomegalovirus
KW - lung transplantation
KW - organ transplantation
U2 - 10.1111/apm.13317
DO - 10.1111/apm.13317
M3 - Journal article
C2 - 37022293
AN - SCOPUS:85153357703
VL - 131
SP - 574
EP - 583
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 11
ER -
ID: 359854511